Bactericidal effect of performic acid on salivary bacteria

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<p>Although heat­sensitive semi­-critical medical devices (e.g., transnasal endoscopes) should undergo high­-level disinfection between patients, these devices are often harmful to humans and the environment due to their residual toxicity caused by disinfectants. We analyzed the bactericidal activity against salivary bacteria of performic acid (PFA) which has strong antibacterial activity and has shown a consistent absence of genotoxic and mutagenic effects on human cells. Collected saliva samples were mixed with various concentrations of PFA. After incubation, bactericidal activity was assessed with colony­-forming assays and quantification of ATP produced by metabolically active cells. Even for a 1­-minute exposure, PFA showed a strong bactericidal effect against salivary bacte­ria, in which more than 99.9% and 67.1% of bacterial colonies were suppressed at 8×10−4 % (w/v) and 8×10−6% (w/v) PFA, respectively. This effect was enhanced by prolonged in­cubation. Bacterial viability assay based on ATP measurement also showed concentration­dependent bactericidal effects of PFA. PFA showed comparatively strong antibacterial activity against salivary bacteria, even with short duration exposure. (J Osaka Dent Univ 2018; 52: 11­-15) </p>

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