Association of N-Terminal Pro B-Type Natriuretic Peptide With Blood Pressure and Pulse Pressure in Elderly People ― A Cross-Sectional Population Study ―
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- Sasaki Nobuo
- Health Management and Promotion Center, Hiroshima Atomic Bomb Casualty Council
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- Yamamoto Hideya
- Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences
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- Ozono Ryoji
- Department of General Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences
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- Fujiwara Saeko
- Health Management and Promotion Center, Hiroshima Atomic Bomb Casualty Council
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- Kihara Yasuki
- Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences
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<p>Background:N-Terminal pro B-type natriuretic peptide (NT-proBNP) is widely used as a marker of ventricular dysfunction. However, data regarding the association of NT-proBNP with blood pressure (BP) and pulse pressure (PP) in the elderly population are limited.</p><p>Methods and Results:The present cross-sectional study involved 6,529 participants, aged ≥70 years, without cardiovascular disease (CVD), who underwent general health examinations. Serum NT-proBNP concentrations were determined, with high NT-proBNP concentrations defined as those ≥125 pg/mL. Subjects were divided into five groups based on PP (<50, ≥50 to <60, ≥60 to <70, ≥70 to <80, and ≥80 mmHg). NT-proBNP was positively associated with systolic BP, whereas a U-shaped association was found between diastolic BP and NT-proBNP. The odds ratios for high NT-proBNP concentrations in the PP ≥80 and ≥70 to <80 mmHg groups (OR 1.83 [P<0.001] and 1.40 [P<0.005], respectively) were significantly higher than in the PP <50 mmHg group. All data were adjusted for age, sex, body mass index, hemoglobin concentration, serum creatinine, pulse rate, smoking, alcohol intake, and antihypertensive medication intake, and the presence of diabetes and dyslipidemia.</p><p>Conclusions:The results suggest that NT-proBNP concentrations may be a marker of not only ventricular dysfunction, but also arterial stiffness in the elderly population without CVD.</p>
収録刊行物
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- Circulation Journal
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Circulation Journal 82 (8), 2049-2054, 2018-07-25
一般社団法人 日本循環器学会
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詳細情報 詳細情報について
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- CRID
- 1390564238001909248
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- NII論文ID
- 130007419554
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- NII書誌ID
- AA11591968
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- ISSN
- 13474820
- 13469843
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- NDL書誌ID
- 029111484
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- PubMed
- 29794411
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可