Sex Differences in the Prognostic Power of Brain Natriuretic Peptide and N-Terminal Pro-Brain Natriuretic Peptide for Cardiovascular Events　― The Japan Morning Surge-Home Blood Pressure Study ―

• Taki Mizuri

  Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine

• Ishiyama Yusuke

  Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine

• Mizuno Hiroyuki

  Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine

• Komori Takahiro

  Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine

• Kono Ken

  Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine

• Hoshide Satoshi

  Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine

• Kario Kazuomi

  Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine

抄録

Background:Brain natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) are prognostic biomarkers. Although these 2 peptides differ with regard to biological characteristics, there are few reports on the differences between BNP and NT-proBNP with regard to cardiovascular events or according to sex. Methods and Results:Between 2005 and 2012, this study analyzed 3,610 of 4,310 Japanese outpatients (mean age, 65 years; men, n=1,664; women, n=1,947) with a history of at least one cardiovascular event who were recruited to the Japan Morning Surge-Home Blood Pressure Study. During an average 4-year follow-up, there were 129 cardiovascular events. Both median BNP (21.1 pg/mL; IQR, 10.9–40.6 pg/mL vs. 16.2 pg/mL, IQR, 7.2–36.2 pg/mL, P<0.001) and median NT-proBNP (54.7 pg/mL; IQR, 30.2–102.6 pg/mL vs. 44.9 pg/mL, IQR, 20.7–92.6 pg/mL, P<0.001) were significantly higher in women than in men. A 1-SD increment in log-transformed BNP (hazard ratio [HR], 2.18; 95% CI: 1.53–3.10) and NT-proBNP (HR, 2.39; 95% CI: 1.73–3.31) was associated with a significant increase in cardiovascular events in women; in men, only NT-proBNP showed this association. There was an interaction between log-transformed BNP (P=0.007) or NT-proBNP (P=0.001) and cardiovascular events according to sex. Conclusions:Both BNP and NT-proBNP predicted cardiovascular outcomes in a large Japanese clinical population. BNP and NT-proBNP were significantly stronger predictors in women than in men.

収録刊行物

• Circulation Journal

  Circulation Journal 82 (8), 2096-2102, 2018-07-25

  一般社団法人 日本循環器学会

キーワード

• Brain natriuretic peptide
• N-terminal pro-brain natriuretic peptide
• Prognostic biomarker
• Sex difference

詳細情報

• CRID: 1390001288047712512
• NII論文ID: 130007419905
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.cj-18-0375
• ISSN: 13474820
• ISSN: 13469843
• NDL書誌ID: 029111555
• PubMed: 29925742
• Web Site: http://id.ndl.go.jp/bib/029111555
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I029111555
• Web Site: https://www.jstage.jst.go.jp/article/circj/82/8/82_CJ-18-0375/_pdf
• 本文言語コード: en
• データソース種別:
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  • NDL
  • Crossref
  • PubMed
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  • KAKEN
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