Increased Oral <i>Porphyromonas gingivalis</i> Prevalence in Cardiovascular Patients with Uncontrolled Diabetes Mellitus
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- Aoyama Norio
- Division of Periodontology, Department of Oral Interdisciplinary Medicine, Graduate School of Dentistry, Kanagawa Dental University
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- Suzuki Jun-ichi
- Department of Advanced Clinical Science and Therapeutics, The University of Tokyo Department of Cardiovascular Medicine, Tokyo Medical and Dental University
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- Kobayashi Naho
- Department of Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
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- Hanatani Tomoya
- Department of Periodontology, Kyushu Dental University
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- Ashigaki Norihiko
- Department of Oral Microbiology, Tsurumi University
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- Yoshida Asuka
- Department of Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
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- Shiheido Yuka
- Department of Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
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- Sato Hiroki
- Department of Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
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- Izumi Yuichi
- Department of Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
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- Isobe Mitsuaki
- Department of Cardiovascular Medicine, Tokyo Medical and Dental University
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Abstract
<p>The aim of this study was to determine the correlation between periodontopathic bacteria and diabetes mellitus (DM) status in cardiovascular disease (CVD) subjects.</p><p>DM is associated with the progression of periodontitis. Several epidemiological studies have suggested that periodontitis may be a risk factor for CVD. However, no study has compared the periodontal condition between well-controlled and poorly-controlled DM patients with CVD.</p><p>The subjects were well-controlled (n = 73) or poorly-controlled (n = 39) DM patients with CVD. Blood examinations and dental clinical measurements, including number of teeth, probing pocket depth, bleeding on probing (BOP), and clinical attachment level (CAL) were performed. Periodontopathic bacterial existence was evaluated.</p><p>Worsened CAL and BOP rate were detected in the uncontrolled DM group compared to the controlled group. We found increased salivary Porphyromonas gingivalis counts in the uncontrolled DM group compared to well-controlled DM subjects.</p><p>Specific periodontopathic bacterial infection may affect DM condition in CVD patients.</p>
Journal
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- International Heart Journal
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International Heart Journal 59 (4), 802-807, 2018-07-31
International Heart Journal Association