新規エクジステロイド生合成因子Noppera-boを標的とした創農薬研究

• 藤川 雄太

  東京薬科大学生命科学部分子生物化学研究室

• 井上 英史

  東京薬科大学生命科学部分子生物化学研究室

書誌事項

タイトル別名

• Exploration of Insect Growth Regulators Targeting Noppera-bo, an Enzyme Involved in Ecdysteroid Biosynthesis
• Symposium Review 新規エクジステロイド生合成因子Noppera-boを標的とした創農薬研究
• Symposium Review シンキ エクジステロイド セイゴウセイ インシ Noppera-bo オ ヒョウテキ ト シタ ソウノウヤク ケンキュウ

抄録

 Insect growth regulators (IGRs) are chemicals that adversely affect the physiological processes associated with insect development and cause abnormalities that impair insect survival. Ecdysone, an insect steroid hormone originally identified as a molting hormone, plays an essential role in developmental transition, such as during molting and metamorphosis. Recently, a member of the epsilon class of glutathione S-transferases (GST), GSTe14, also called Noppera-bo (Nobo), has been identified as essential for regulating the biosynthesis of ecdysone. Knockout or knockdown of the nobo gene causes ecdysone deficiency, leading to either death or arrested phenotype development at the larval stage. It is therefore considered that Nobo is potentially well suited as a target for novel IGRs. In this review, we focus on the development of a high-throughput screening strategy for Nobo inhibitors using a GST fluorogenic substrate.<br>

収録刊行物

• 薬学雑誌

  薬学雑誌 138 (8), 1043-1048, 2018-08-01

  公益社団法人 日本薬学会

キーワード

• insect growth regulator
• glutathione <i>S</i>-transferase
• Noppera-bo

詳細情報

• CRID: 1390282763026804736
• NII論文ID: 130007429055
• NII書誌ID: AN00284903
• DOI: 10.1248/yakushi.17-00211-3
• ISSN: 13475231
• ISSN: 00316903
• NDL書誌ID: 029185063
• PubMed: 30068845
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I029185063
• Web Site: https://www.jstage.jst.go.jp/article/yakushi/138/8/138_17-00211-3/_pdf
• 本文言語コード: ja
• データソース種別:
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  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可