Clarification of the Mechanism Involved in Orexigenic Action by Oral Zinc Ingestion

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  • Komai Michio
    Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University
  • Goto Tomoko
    Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University
  • Ohinata Kousaku
    Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
  • Kambe Taiho
    The Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University
  • Mayanagi Yuki
    Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University
  • Shirakawa Hitoshi
    Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University

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Other Title
  • 消化管亜鉛シグナルによる食欲亢進作用のメカニズム
  • Symposium Review 消化管亜鉛シグナルによる食欲亢進作用のメカニズム
  • Symposium Review ショウカカン アエン シグナル ニ ヨル ショクヨク コウシン サヨウ ノ メカニズム

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Abstract

 We investigated the role of zinc in regulation of food intake using male SD rats during early-stage of zinc deficiency (the 3rd day of the feeding) without decreased zinc concentrations in tissues (hypothalamus and liver). As a result, we found that orally but not intraperitoneal administered zinc stimulates food intake in the short-term zinc-deficient rats. The mRNA expressions of hypothalamic peptides, such as orexin (OX) and neuropeptide Y (NPY), were increased after oral administration of zinc to increase food intake. Pretreatment with an antagonist for the NPY Y1 receptor or the orexin OX1 receptor blocked orexigenic activity by zinc administration. The stimulation of food intake by oral administration of zinc was also abolished by vagotomy. Taken together, our results indicate that zinc stimulates food intake in short-term zinc-deficient rats through the afferent vagus nerve followed by activating the hypothalamic peptide associated with food intake regulation. This study showed the first evidence that gastrointestinal zinc signal is indispensable for the food appetite induction in the experimentally anorexigenic rat. However, since it has not yet been clarified the mechanism involved in zinc sensing by the epithelial membrane of the gastrointestinal tract, further detailed investigations are necessary.<br>

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 138 (8), 1011-1016, 2018-08-01

    The Pharmaceutical Society of Japan

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