Importin alpha: Functions as a nuclear transport factor and beyond

• OKA Masahiro

  National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)

• YONEDA Yoshihiro

  National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN)

書誌事項

タイトル別名

• Importin α: functions as a nuclear transport factor and beyond

抄録

Nucleocytoplasmic transport is an essential process in eukaryotes. The molecular mechanisms underlying nuclear transport that involve the nuclear transport receptor, small GTPase Ran, and the nuclear pore complex are highly conserved from yeast to humans. On the other hand, it has become clear that the nuclear transport system diverged during evolution to achieve various physiological functions in multicellular eukaryotes. In this review, we first summarize the molecular mechanisms of nuclear transport and how these were elucidated. Then, we focus on the diverse functions of importin α, which acts not merely an import factor but also as a multi-functional protein contributing to a variety of cellular functions in higher eukaryotes.

収録刊行物

• Ｐｒｏｃｅｅｄｉｎｇｓ　ｏｆ　ｔｈｅ　Ｊａｐａｎ　Ａｃａｄｅｍｙ．　Ｓｅｒ．　Ｂ：　Ｐｈｙｓｉｃａｌ　ａｎｄ　Ｂｉｏｌｏｇｉｃａｌ　Ｓｃｉｅｎｃｅｓ

  Ｐｒｏｃｅｅｄｉｎｇｓ　ｏｆ　ｔｈｅ　Ｊａｐａｎ　Ａｃａｄｅｍｙ．　Ｓｅｒ．　Ｂ：　Ｐｈｙｓｉｃａｌ　ａｎｄ　Ｂｉｏｌｏｇｉｃａｌ　Ｓｃｉｅｎｃｅｓ 94 (7), 259-274, 2018-08-03

  日本学士院

キーワード

• nuclear transport
• nuclear localization signal
• small GTPase Ran
• nuclear pore-targeting complex
• importin α
• importin β

詳細情報

• CRID: 1390001288049816448
• NII論文ID: 130007430327
• NII書誌ID: AA00785485
• DOI: 10.2183/pjab.94.018
• ISSN: 13492896
• ISSN: 03862208
• NDL書誌ID: 029167093
• PubMed: 30078827
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I029167093
• Web Site: https://www.jstage.jst.go.jp/article/pjab/94/7/94_PJA9407B-01/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2019173682
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可