<b>Analgesic effect of mineral cream containing natural spa minerals for use on the </b><b>skin </b>
-
- HIRABAYASHI Takahiro
- Global Research Center for Innovative Life Science, Hoshi University
-
- YAMASHITA Michio
- Global Research Center for Innovative Life Science, Hoshi University Department of Exercise and Sports Physiology, School of Pharmacy and Pharmaceutical Sciences, Hoshi University
-
- WADA Nobuhiro
- Global Research Center for Innovative Life Science, Hoshi University
-
- TAKENOYA Fumiko
- Department of Exercise and Sports Physiology, School of Pharmacy and Pharmaceutical Sciences, Hoshi University
-
- IKEDA Hiroko
- Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University
-
- KAMEI Junzo
- Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University
-
- RYUSHI Tomoo
- Faculty of Sports and Health Science, Department of Sports Science, Daito Bunka University
-
- YAMAMOTO Noriyuki
- Department of Health Sciences, Japanese Red Cross Hokkaido College of Nursing
-
- SHIODA Seiji
- Global Research Center for Innovative Life Science, Hoshi University
この論文をさがす
抄録
<p>Previous studies have shown that dissolved substances in some natural hot springs have analgesic/anti-nociceptive and anti-inflammatory actions. However, the mechanisms underlying how such dissolved substances exert these actions are not fully understood. In the present study on mice, we examined the analgesic/anti-nociceptive and anti-inflammatory properties of a mineral cream containing natural hot spring ingredients. The anti-nociceptive effects of the mineral cream were assessed by using the von Frey test. Application of the mineral cream to the hind paw of mice produced a significant anti-nociceptive effect compared to control. The anti-nociceptive effects of the mineral cream were also assessed following the injection of complete Freund’s adjuvant (CFA) into the hind paws of mice after pre-treatment for one or four weeks with the mineral cream. Histological experiments with light microscopy showed that the mineral cream did not reduce inflammation caused by the CFA treatment. In addition, the mineral cream did not inhibit oxidative stress as evidenced by increased levels of oxidative metabolites (d-ROMs) and biological anti-oxidant potential (BAP). These results suggest that the mineral cream does not exert a protective effect against inflammation, and that the constituents of the mineral cream may produce their anti-nociceptive effects transdermally via different mechanisms including the nervous system.</p>
収録刊行物
-
- Biomedical Research
-
Biomedical Research 39 (4), 215-222, 2018-08-01
バイオメディカルリサーチプレス