Prognostic impact of preoperative lymphocyte-to-monocyte ratio in patients with colorectal cancer with special reference to myeloid-derived suppressor cells

DOI 機関リポジトリ Web Site PubMed 参考文献23件
  • Shimura Tatsuo
    Department of Progressive DOHaD Research, Fukushima Medical University
  • Shibata Masahiko
    Department of Advanced Cancer Immunotherapy, Fukushima Medical University
  • Gonda Kenji
    Clinical Oncology Center, Fukushima Medical University
  • Hayase Suguru
    Department of Gastrointestinal Tract Surgery, Fukushima Medical University
  • Sakamoto Wataru
    Department of Gastrointestinal Tract Surgery, Fukushima Medical University
  • Okayama Hirokazu
    Department of Gastrointestinal Tract Surgery, Fukushima Medical University
  • Fujita Shotaro
    Department of Gastrointestinal Tract Surgery, Fukushima Medical University
  • Saito Motonobu
    Department of Gastrointestinal Tract Surgery, Fukushima Medical University
  • Momma Tomoyuki
    Department of Gastrointestinal Tract Surgery, Fukushima Medical University
  • Ohki Shinji
    Department of Gastrointestinal Tract Surgery, Fukushima Medical University
  • Kono Koji
    Department of Gastrointestinal Tract Surgery, Fukushima Medical University

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<p>Aims: We aimed to investigate the relationship of colorectal cancer prognosis and inflammatory parameters, including neutrophil-to-lymphocyte ratio (NLR) and lymphocyte-to-monocyte ratio (LMR), with reference to circulating myeloid-derived suppressor cells (MDSCs) in the current study.</p><p>Patients and Methods: Thirty-five patients who underwent curative-intent surgery were enrolled.　A receiver-operating characteristic curve (ROC) was used to assess the usefulness of candidates for prognostic factors. Recurrence-free survival (RFS) was calculated using the Kaplan-Meier method, and the candidates for prognostic factors were assessed by a Cox proportional hazard model.</p><p>Results: ROC curve analyses determined cutoff values for NLR and LMR as 2.9 and 2.4, respectively. The percentage of MDSCs in patients with LMR ≤ 2.4 was statistically higher than in those with LMR > 2.4 (p = 0.012). The patients with LMR ≤ 2.4 exhibited a statistically lower RFS than those with LMR > 2.4 (p = 0.008). These results were also observed in patients with stage II + III disease. LMR was an independent prognostic factor of RFS in colorectal cancer patients (hazard ratio: 7.757, 95% confidence interval: 1.462-41.152, p = 0.016).</p><p>Conclusion: Lower LMR was associated with poor prognosis in colorectal cancer patients; whereas, higher circulating MDSCs were observed in patients with lower LMR.</p>

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