Intranuclear Mobility of Estrogen Receptor: Implication for Transcriptional Regulation

• Matsuda Ken Ichi

  Department of Anatomy and Neurobiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine

• Hashimoto Takashi

  Division of Anatomy and Neuroscience, Department of Morphological and Physiological Sciences, University of Fukui Faculty of Medical Sciences

• Kawata Mitsuhiro

  School of Health Sciences, Bukkyo University

抄録

The estrogen receptor (ER) is a ligand-dependent transcription factor that has two subtypes: ERα and ERβ. ERs regulate transcription of estrogen-responsive genes through interactions with multiple intranuclear components, such as cofactors and the nuclear matrix. Live cell imaging using fluorescent protein-labeled ERs has revealed that ligand-activated ERs are highly mobile in the nucleus, with transient association with the DNA and nuclear matrix. Scaffold attachment factor B (SAFB) 1 and its paralogue, SAFB2, are nuclear matrix-binding proteins that negatively modulate ERα-mediated transcription. Expression of SAFB1 and SAFB2 reduces the mobility of ERα in the presence of ligand. This regulatory machinery is emerging as an epigenetic-like mechanism that alters transcriptional activity through control of intranuclear molecular mobility.

収録刊行物

• Ａｃｔａ　Ｈｉｓｔｏｃｈｅｍｉｃａ　ｅｔ　Ｃｙｔｏｃｈｅｍｉｃａ

  Ａｃｔａ　Ｈｉｓｔｏｃｈｅｍｉｃａ　ｅｔ　Ｃｙｔｏｃｈｅｍｉｃａ 51 (4), 129-136, 2018-08-29

  日本組織細胞化学会

キーワード

• estrogen receptor
• living imaging
• FRAP
• SAFB
• nuclear matrix

詳細情報

• CRID: 1390001288064689664
• NII論文ID: 130007470747
• DOI: 10.1267/ahc.18023
• ISSN: 13475800
• ISSN: 00445991
• Web Site: https://www.jstage.jst.go.jp/article/ahc/51/4/51_18023/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2019187718
• 本文言語コード: en
• データソース種別:
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  • Crossref
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