Anticancer agent 6-MITC at extremely low dosage can control seizures by stabilizing membrane excitability system in mutant EL mice

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  • Murashima Yoshiya L.
    Department of Health Promotion Science, Tokyo Metropolitan University Graduate School of Human Health Science
  • Shinoda Shoko
    Department of Health Promotion Science, Tokyo Metropolitan University Graduate School of Human Health Science
  • Fuke Yoko
    Department of Health Promotion Science, Tokyo Metropolitan University Graduate School of Human Health Science

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<p>Recently, attention has been focused on the anticancer properties of an aromatic component; 6-(methylsulfinyl) hexyl isothiocyanate (6-MITC), in a typical Japanese spice, wasabi. 6-MITC shows selective sensitivity to human breast cancer and melanoma cell lines in 39 human cancer cell lines. Furthermore, 6-MITC is active against pulmonary metastasis of B16-BL6 mouse melanoma cells. In the present study, we investigated the antiepileptic effects of 6-MITC using epileptic mutant EL mice. To explore the mechanisms of antiepileptic effects of 6-MITC, we analyzed the changes in cell cycle reentry (CCR), cytokine systems, and GABAA receptor subunits during epileptogenesis in EL mice, using semi-quantitative Western blotting techniques. Our results suggest that the antiepi-leptic mechanisms of 6-MITC is related to repair of abnormal plasticity, which is supported by CCR inactivation, together with activation of endogenous cytokines as well as induction of extra-synaptic GABAA receptor subunits, both of which play antiepileptic roles.</p>

収録刊行物

  • Epilepsy & Seizure

    Epilepsy & Seizure 10 (1), 44-51, 2018

    一般社団法人 日本てんかん学会

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