Determination of Serum 25-Hydroxyvitamin D₃ by LC/MS/MS and Its Monthly Variation in Sapporo Indoor Workers

• OKABE Hiroaki

  Faculty of Health Sciences, Hokkaido University

• SHIMIZU Chikara

  Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital

• YAMAMOTO Maiko

  Faculty of Health Sciences, Hokkaido University

• KIKUCHI Rei

  Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital

• MINAMI Akiko

  Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital

• CHEN Yi-Fan

  Graduate School of Information Science and Technology, Hokkaido University

• IMAI Hideyuki

  Graduate School of Information Science and Technology, Hokkaido University

• MIZUTA Masahiro

  Graduate School of Information Science and Technology, Hokkaido University

• CHEN Zhen

  Faculty of Health Sciences, Hokkaido University

• CHIBA Hitoshi

  Department of Nutrition, Sapporo University of Health Sciences

• HUI Shu-Ping

  Faculty of Health Sciences, Hokkaido University

書誌事項

タイトル別名

• Determination of Serum 25-Hydroxyvitamin D₃ by LC/MS/MS and Its Monthly Variation in Sapporo Indoor Workers

抄録

25-Hydroxyvitamin D₃ (25(OH)D₃) as the metabolite of vitamin D, is connected with various of diseases, and important to people with limited sunshine. Thus, the investigation of serum 25-hydroxyvitamin D and its variation in these people is necessary. In this study, a simple, precise, and accurate method for serum 25(OH)D₃ determination by LC/MS/MS was developed. Serum samples were obtained monthly for one year from 11 male and 11 female indoor workers in Sapporo, Japan, and the overall 25(OH)D₃ concentration was 12.9 ± 4.7 ng/mL. The 25(OH)D₃ in females was significantly lower than that in males (14.0 ± 5.0 vs. 11.9 ± 4.3 ng/mL). The serum 25(OH)D₃ concentration in males and females were both strongly correlated to UV-B radiation (r² = 0.8477 and 0.7384, respectively), with a two-month’s lag. Also the monthly change in 25(OH)D₃ in males was more significant than that in females.

収録刊行物

• Analytical Sciences

  Analytical Sciences 34 (9), 1043-1047, 2018-09-10

  社団法人 日本分析化学会

キーワード

• 25-Hydroxy vitamin D₃
• LC/MS/MS
• UV-B
• monthly variation

詳細情報

• CRID: 1390564238019449728
• NII論文ID: 130007474724
• NII書誌ID: AA10500785
• DOI: 10.2116/analsci.18p193
• ISSN: 13482246
• ISSN: 09106340
• HANDLE: 2115/71895
• NDL書誌ID: 029215275
• PubMed: 29863032
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I029215275
• Web Site: https://link.springer.com/content/pdf/10.2116/analsci.18P193.pdf
• Web Site: https://link.springer.com/article/10.2116/analsci.18P193/fulltext.html
• Web Site: https://www.jstage.jst.go.jp/article/analsci/34/9/34_18P193/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2019147705
• 本文言語コード: en
• データソース種別:
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  • IRDB
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
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