Macrophage Uptake Behavior and Anti-inflammatory Response of Bovine Brain- or Soybean-derived Phosphatidylserine Liposomes

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  • Toita Riki
    Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST) AIST-Osaka University Advanced Photonics and Biosensing Open Innovation Laboratory
  • Fujita Satoshi
    Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST) AIST-Osaka University Advanced Photonics and Biosensing Open Innovation Laboratory
  • Kang Jeong-Hun
    Division of Biopharmaceutics and Pharmacokinetics, National Cerebral and Cardiovascular Center Research Institute

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<p>Phosphatidylserine (PtdSer) is mainly derived from the bovine brain cortex or soybean lecithin. We investigated macrophage uptake behavior and the anti-inflammatory response induced by liposomes containing bovine brain- (B-PSL) or soybean-derived PtdSer (S-PSL). The size of B-PSL and S-PSL was very similar. There were no significant differences in the uptake of B-PSL and S-PSL by Raw 264.7 macrophage cells. Addition of B-PSL or S-PSL decreased the production of the inflammatory cytokines, IL-1α, IL-6 and TNF-α, in lipopolysaccharide-treated Raw 264.7 cells, but there were no differences between them. These results suggest that S-PSL may be used as an anti-inflammatory agent.</p>

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