Screening Validity of Arterial Pressure–Volume Index and Arterial Velocity–Pulse Index for Preclinical Atherosclerosis in Japanese Community-Dwelling Adults: the Nagasaki Islands Study
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- Yamanashi Hirotomo
- Department of Island and Community Medicine, Nagasaki University Graduate School of Biomedical Sciences Department of Clinical Medicine, Institute of Tropical Medicine, Nagasaki University
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- Koyamatsu Jun
- Department of Island and Community Medicine, Nagasaki University Graduate School of Biomedical Sciences
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- Nagayoshi Mako
- Department of Community Medicine, Nagasaki University Graduate School of Biomedical Sciences
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- Shimizu Yuji
- Department of Community Medicine, Nagasaki University Graduate School of Biomedical Sciences
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- Kawashiri Shin-ya
- Department of Community Medicine, Nagasaki University Graduate School of Biomedical Sciences
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- Kondo Hideaki
- Department of Community Medicine, Nagasaki University Graduate School of Biomedical Sciences
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- Fukui Shoichi
- Department of Community Medicine, Nagasaki University Graduate School of Biomedical Sciences
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- Tamai Mami
- Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences
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- Maeda Takahiro
- Department of Island and Community Medicine, Nagasaki University Graduate School of Biomedical Sciences Department of Community Medicine, Nagasaki University Graduate School of Biomedical Sciences
抄録
<p>Aim: The arterial pressure–volume index (API) and arterial velocity–pulse index (AVI) are novel measurement indices of arterial stiffness. This study was performed to examine the screening validity of the API and AVI for preclinical atherosclerosis in Japanese community-dwelling adults.</p><p>Methods: We conducted a cross-sectional study of 2,809 participants aged ≥40 years who underwent Japanese national medical check-ups from 2014 to 2016. Preclinical atherosclerosis was defined as a mean carotid intima–media thickness (CIMT) of ≥1.0 mm. Multivariable linear regression analysis was performed to investigate the association of CIMT with API and AVI, adjusting for body mass index, sex, and the Framingham–D'Agostino score. We also examined receiver operating characteristic curves, sensitivity, and specificity to predict preclinical atherosclerosis defined by the CIMT. The cardio-ankle vascular index was also measured for comparison with the API and AVI.</p><p>Results: Of 2,809 participants, 68 (2.4%) had preclinical atherosclerosis. In the multivariable linear regression analysis, the API and AVI maintained a positive association with the mean CIMT (B=2.6, P=0.009 and B=3.7, P=0.001, respectively). The cut-offs of the API and AVI that demonstrated better sensitivity and specificity for detection of subclinical atherosclerosis were 31 [area under the curve (AUC), 0.64] and 29 (AUC, 0.60).</p><p>Conclusions: The API and AVI were positively associated with preclinical carotid atherosclerosis independent of the participants' cardiovascular risk. The ability of these scores to predict carotid atherosclerosis could make them a useful screening tool for atherosclerosis.</p>
収録刊行物
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- Journal of Atherosclerosis and Thrombosis
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Journal of Atherosclerosis and Thrombosis 25 (9), 792-798, 2018-09-01
一般社団法人 日本動脈硬化学会
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詳細情報 詳細情報について
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- CRID
- 1390001288065059200
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- NII論文ID
- 130007479702
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- ISSN
- 18803873
- 13403478
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- HANDLE
- 10069/38736
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- PubMed
- 29398680
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可