Sex differences in associations among metabolic syndrome, obesity, related biomarkers, and colorectal adenomatous polyp risk in a Japanese population

• Nakai Keisuke

  Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine

• Watari Jiro

  Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine

• Tozawa Katsuyuki

  Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine

• Tamura Akio

  Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine

• Hara Ken

  Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine

• Yamasaki Takahisa

  Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine

• Kondo Takashi

  Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine

• Kono Tomoaki

  Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine

• Tomita Toshihiko

  Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine

• Ohda Yoshio

  Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine

• Oshima Tadayuki

  Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine

• Fukui Hirokazu

  Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine

• Sakurai Jun

  Department of Gastroenterology, Meiwa Hospital

• Kim Yongmin

  Department of Gastroenterology, Meiwa Hospital

• Hayakawa Yuji

  Department of Gastroenterology, Meiwa Hospital

• Fujisawa Takashi

  Department of Gastroenterology, Steel Memorial Hirohata Hospital

• Morimoto Takeshi

  Department of Clinical Epidemiology, Hyogo College of Medicine

• Miwa Hiroto

  Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine

抄録

To investigate sex differences in the associations among metabolic syndrome, obesity, adipose tissue-related biomarkers, and colorectal adenomatous polyps, a cross-sectional, multicenter study was conducted on 489 consecutive individuals who underwent their first colonoscopy at 3 hospitals. Plasma concentrations of adiponectin and leptin, as well as homeostatic model assessment of insulin resistance were also evaluated. The presence and number of adenomatous polyps, including advanced adenoma, were higher in men than in women. Metabolic syndrome was a risk factor for adenomatous polyps in both sexes. Large waist circumference was an independent risk factor for adenomatous polyps in men, and high BMI and large waist circumference were risk factors for adenomatous polyps in women. Interestingly, low BMI was associated with large adenomatous polyps (≥10 mm) and advanced adenoma, and waist-hip ratio was involved in proximal adenomatous polyp development only in women. In contrast, the highest quartile of leptin concentration had a 3.67-fold increased adenomatous polyp risk compared with the lowest quartile only in men. These results indicate that regarding colorectal pathogenesis, sex differences were identified in obesity but not in metabolic syndrome. Visceral obesity and a high serum leptin level may be risk factors for colorectal adenomatous polyp development in Japanese men.

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ｃｌｉｎｉｃａｌ　Ｂｉｏｃｈｅｍｉｓｔｒｙ　ａｎｄ　Ｎｕｔｒｉｔｉｏｎ

  Ｊｏｕｒｎａｌ　ｏｆ　Ｃｌｉｎｉｃａｌ　Ｂｉｏｃｈｅｍｉｓｔｒｙ　ａｎｄ　Ｎｕｔｒｉｔｉｏｎ 63 (2), 154-163, 2018

  一般社団法人　日本酸化ストレス学会

キーワード

• sex difference
• metabolic syndrome
• visceral obesity
• colorectal adenoma
• adipokine

詳細情報

• CRID: 1390001288063843456
• NII論文ID: 130007479962
• DOI: 10.3164/jcbn.18-11
• ISSN: 18805086
• ISSN: 09120009
• Web Site: https://www.jstage.jst.go.jp/article/jcbn/63/2/63_18-11/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2019146370
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可