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- KAMO Masashi
- 産業技術総合研究所
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- 岩崎 雄一
- 東洋大学
書誌事項
- タイトル別名
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- Comparison of Predicted No Effect Concentrations(PNECs)Derived by Using Assessment Factor and Species Sensitivity Distribution methods
- アセスメント ケイスウ オ モチイル ホウホウ ト タネ ノ カンジュ ショウブンフ ホウホウ カラ ドウシュツ サレル ヨソク ムエイキョウ ノウド(PNEC)ノ ヒカク
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抄録
Running laboratory toxicity tests is costly and time consuming, and therefore extrapolations based on the limited toxicological information are necessary in performing the ecological risk assessment/management of chemical substances. Two widely-used extrapolation methods are the use of assessment factors(AF)as adopted in, for example, the Japanese chemical substances control law, and the other is the application of species sensitivity distribution(SSD). In this study, we theoretically investigated the performance of two extrapolation methods by comparing predicted no effect concentrations(PNECs)derived by the methods. For the comparison, two criteria were adopted. One criterion considers that an extrapolation method which derives a PNEC smaller than the hazardous concentration for 5% of species(HC5)with higher possibility is better. Another criterion considers that an extrapolation method which sets a PNEC closer to the HC5 is better. The AF method adopted by the chemical substances control law was superior under the first criterion but was inferior under the second criterion. Our results show that there is no unique assessment method that always defeat the others, and thereby suggests that a better strategy may be required to compile the merits of existing extrapolation methods depending on data and goal of protection in risk assessments.
収録刊行物
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- 環境毒性学会誌
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環境毒性学会誌 19 (1), 47-58, 2016-06-30
日本環境毒性学会
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キーワード
詳細情報 詳細情報について
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- CRID
- 1390282763040935296
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- NII論文ID
- 130007481306
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- NII書誌ID
- AA11495647
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- ISSN
- 18825958
- 13440667
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- NDL書誌ID
- 027579360
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可