Effect of hindlimb unloading and reloading on the soleus and plantaris muscles in diabetic rats

• Madokoro Sachiko

  Division of Health Sciences, Graduate School of Medical Science, Kanazawa University: 5-11-80 Kodatsuno, Kanazawa, lshikawa 920-0942, Japan

• Inaoka Pleiades Tiharu

  Division of Health Sciences, Graduate School of Medical Science, Kanazawa University: 5-11-80 Kodatsuno, Kanazawa, lshikawa 920-0942, Japan

• Tanaka Shoji

  Division of Health Sciences, Graduate School of Medical Science, Kanazawa University: 5-11-80 Kodatsuno, Kanazawa, lshikawa 920-0942, Japan

• Yamazaki Toshiaki

  Division of Health Sciences, Graduate School of Medical Science, Kanazawa University: 5-11-80 Kodatsuno, Kanazawa, lshikawa 920-0942, Japan

Abstract

[Purpose] This study aimed to induce disuse muscle atrophy in Goto-Kakizaki rats, a type 2 diabetes model, to investigate the effects of reloading on the soleus and plantaris muscles. [Materials and Methods] Wistar and Goto-Kakizaki (GK) rats were divided into 6 groups: Wistar Control (WC), GK Control (GC), Wistar Tail suspension (WS), GK Tail suspension (GS), and Wistar Reload (WR), GK Reload (GR). [Results] Investigation of myofiber cross-sectional area in Goto-Kakizaki rat soleus muscles indicated that the GS group showed significantly lower values than the GC and GR groups. No significant differences were observed between the GC and GR groups. However, investigation of plantaris muscles in Goto-Kakizaki rats indicated that the GS and GR groups showed a significant decrease compared to the GC group. No significant differences were found between the GS and GR groups. [Conclusion] Investigation of muscle weight/body weight ratios and myofiber cross-sectional area in tail suspension groups confirmed the induction of muscular atrophy. The differences in the degree of atrophy and recovery in terms of myofiber cross-sectional area observed in Goto-Kakizaki rat plantaris muscles may be influenced by the myofiber type and diabetes.

Journal

• Journal of Physical Therapy Science

  Journal of Physical Therapy Science 30 (9), 1150-1155, 2018

  The Society of Physical Therapy Science

Keywords

• Tail suspension
• Reloading
• Diabetic rat

Details

• CRID: 1390282763040085760
• NII Article ID: 130007481313
• DOI: 10.1589/jpts.30.1150
• ISSN: 21875626
• ISSN: 09155287
• Web Site: https://www.jstage.jst.go.jp/article/jpts/30/9/30_jpts-2018-154/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2020089762
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed