Effects of anti-allergic drugs on T cell-mediated nasal hyperresponsiveness in a murine model of allergic rhinitis

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著者

    • Nishimura Tomoe
    • Allergy and Immunology Project, Tokyo Metropolitan Institute of Medical Science
    • Kaminuma Osamu
    • Allergy and Immunology Project, Tokyo Metropolitan Institute of Medical Science|Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital|Center for Life Science Research, University of Yamanashi
    • Saeki Mayumi
    • Allergy and Immunology Project, Tokyo Metropolitan Institute of Medical Science
    • Kitamura Noriko
    • Allergy and Immunology Project, Tokyo Metropolitan Institute of Medical Science
    • Gotoh Minoru
    • Allergy and Immunology Project, Tokyo Metropolitan Institute of Medical Science
    • Mori Akio
    • Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital
    • Hiroi Takachika
    • Allergy and Immunology Project, Tokyo Metropolitan Institute of Medical Science

抄録

<p><i>Background:</i> We have recently demonstrated that T cell-mediated nasal hyperresponsiveness (NHR) is a representative pathophysiological feature of allergic rhinitis (AR). Although several anti-allergic drugs are used for the treatment of AR, the efficacy of these drugs on T cell-mediated NHR have not been elucidated. In these studies we investigated the effects of dexamethasone (Dex), montelukast (Mk), and chlorpheniramine (Chl) on NHR in antigen-immunized and antigen-specific Th2 cell-transferred mice.</p><p><i>Methods:</i> OVA-immunized BALB/c mice were treated with Dex, Mk, or Chl and challenged intranasally with OVA. We then assessed NHR, the number of inflammatory cells in the nasal lavage fluid (NALF), mRNA expression of Th2 cytokines in the nasal tissue, the population of CD3<sup>+</sup>CD4<sup>+</sup> cells in the nasal lymphoid tissue (NALT), and antigen-specific serum IgE and IgG levels. Antigen-induced NHR and changes in antigen-specific T cells in the NALT were investigated in OVA-specific Th2 cell-transferred mice.</p><p><i>Results:</i> Dex significantly suppressed antigen-induced NHR, inflammatory cell infiltration, and IL-4, IL-5, IL-6, and IL-13 expression in immunized mice. Chl was completely ineffective, and only IL-13 expression was suppressed by Mk. None of these drugs affected IgE and IgG production. Antigen-induced NHR and the increase in antigen-specific T cells in the NALT of Th2 cell-transferred mice were inhibited by Dex, but not by Mk or Chl.</p><p><i>Conclusions:</i> Steroids are effective for the reduction of NHR in AR by suppressing the accumulation of inflammatory cells, especially antigen-specific T cells.</p>

収録刊行物

  • Allergology International

    Allergology International 67(Supplement.1), S25-S31, 2018

    一般社団法人日本アレルギー学会

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