Eligibility of Feline Calicivirus for a Surrogate of Human Norovirus in Comparison with Murine Norovirus, Poliovirus and Coxsackievirus
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- OHMINE TAKAHITO
- Department of Virology, Graduate School of Biomedical and Health Sciences, Hiroshima University
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- NARAI SEIKA
- Department of Virology, Graduate School of Biomedical and Health Sciences, Hiroshima University
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- MATSUBARA TOSHIKI
- Department of Virology, Graduate School of Biomedical and Health Sciences, Hiroshima University
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- NOMURA TOSHIHITO
- Department of Virology, Graduate School of Biomedical and Health Sciences, Hiroshima University
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- ODA KOSUKE
- Department of Virology, Graduate School of Biomedical and Health Sciences, Hiroshima University
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- FUKUSHI MASAYA
- Department of Virology, Graduate School of Biomedical and Health Sciences, Hiroshima University
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- IRIE TAKASHI
- Department of Virology, Graduate School of Biomedical and Health Sciences, Hiroshima University
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- KOMATSU TAKAYUKI
- Department of Microbiology and Immunology, Aichi Medical University School of Medicine
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- TOHYA YUKINOBU
- Laboratory of Veterinary Microbiology, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University
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- SAKAGUCHI TAKEMASA
- Department of Virology, Graduate School of Biomedical and Health Sciences, Hiroshima University
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Abstract
<p>Feline calicivirus (FCV) is frequently used as a surrogate of human norovirus. We investigated eligibility of FCV for anti-viral assay by investigating the stability of infectivity and pH sensitivity in comparison with other viruses. We found that infectivities of FCV and murine norovirus (MNV) are relatively unstable in infected cells compared with those of coxsackievirus (CoV) and poliovirus (PoV) , suggesting that FCV and MNV have vulnerability. Western blotting indicated that inactivation of FCV was not due to viral protein degradation. We also demonstrated sensitivity of FCV to low pH, the 50% inhibitory pH value being ca. 3.9. Since human norovirus is thought to persist longer, in infectivity and to be a resistant virus, CoV, which is robust and not restrained in use as PoV, may be more appropriate as a test virus for disinfectants, rather than FCV and MNV.</p>
Journal
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- Biocontrol Science
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Biocontrol Science 23 (3), 145-149, 2018
The Society for Antibacterial and Antifungal Agents, Japan