Associations of high-density lipoprotein particle and high-density lipoprotein cholesterol with alcohol intake, smoking, and body mass index—The INTERLIPID study

• Zaid Maryam

  Center for Epidemiologic Research in Asia, Shiga University of Medical Science

• Miura Katsuyuki

  Center for Epidemiologic Research in Asia, Shiga University of Medical Science Department of Public Health, Shiga University of Medical Science

• Okayama Akira

  Research Institute of Strategy for Prevention

• Nakagawa Hideaki

  Department of Epidemiology and Public Health, Kanazawa Medical University

• Sakata Kiyomi

  Department of Hygiene and Preventive Medicine, Iwate Medical University

• Saitoh Shigeyuki

  Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine

• Okuda Nagako

  Department of Health and Nutrition, University of Human Arts and Sciences

• Yoshita Katsushi

  Department of Food and Nutrition, Osaka City University

• Choudhury Sohel R.

  National Heart Foundation Hospital and Research Institute

• Rodriguez Beatriz

  Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii and Kuakini Medical Center

• Masaki Kamal

  Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii and Kuakini Medical Center

• Willcox Bradley

  Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii and Kuakini Medical Center

• Miyagawa Naoko

  Department of Public Health, Shiga University of Medical Science

• Okamura Tomonori

  Keio University School of Medicine

• Chan Queenie

  MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London

• Elliott Paul

  MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London

• Stamler Jeremiah

  Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University

• Ueshima Hirotsugu

  Center for Epidemiologic Research in Asia, Shiga University of Medical Science Department of Public Health, Shiga University of Medical Science

• for the INTERLIPID and INTERMAP Research Groups

書誌事項

タイトル別名

• Associations of High-Density Lipoprotein Particle and High-Density Lipoprotein Cholesterol With Alcohol Intake, Smoking, and Body Mass Index　― The INTERLIPID Study ―

抄録

Background: Recently, high-density lipoprotein particles (HDL-P) have been found to be more strongly inversely associated with coronary artery disease (CAD) risk than their counterpart, HDL cholesterol (HDL-C). Given that lifestyle is among the first targets in CAD prevention, we compared the associations of HDL-P and HDL-C with selected lifestyle factors. Methods and Results: We examined 789 Japanese participants of the INTERLIPID Study: men (n=386) and women (n=403) aged 40–59 years in 1996–1998. Participants treated for dyslipidemias were excluded. Lifestyle factors included alcohol intake, smoking amount, and body mass index (BMI). Multivariable linear regression was used for cross-sectional analyses of these factors with HDL-P, HDL-C, HDL-P size subclasses (small, medium and large) and mean HDL-P size. In men, higher alcohol intake was associated with higher HDL-P and higher HDL-C. The associations of alcohol, however, were strongest with HDL-P. A higher smoking amount tended to be associated with lower HDL-P and HDL-C. In contrast, BMI was not associated with HDL-P, but was strongly inversely associated with HDL-C. While alcohol intake favored larger mean HDL-P size, smoking and BMI favored a lipid profile with smaller HDL-P subclasses and overall smaller mean HDL-P size. Similar, but generally weaker results were observed in women. Conclusions: Although both HDL-P and HDL-C are parameters of HDL, they have different associations with alcohol, smoking and BMI.

収録刊行物

• Circulation Journal

  Circulation Journal 82 (10), 2557-2565, 2018-09-25

  一般社団法人 日本循環器学会

キーワード

• Alcohol
• Body mass index
• High-density lipoprotein cholesterol
• High-density lipoprotein particle
• Smoking

詳細情報

• CRID: 1390282763048244352
• NII論文ID: 130007486051
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.cj-18-0341
• ISSN: 13474820
• ISSN: 13469843
• NDL書誌ID: 029230112
• PubMed: 30135319
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I029230112
• Web Site: https://www.jstage.jst.go.jp/article/circj/82/10/82_CJ-18-0341/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2019149436
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可