Cutting Edge of Brain Natriuretic Peptide (BNP) Research　― The Diversity of BNP Immunoreactivity and Its Clinical Relevance ―

• Kuwahara Koichiro

  Department of Cardiovascular Medicine, Shinshu University School of Medicine

• Nakagawa Yasuaki

  Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine

• Nishikimi Toshio

  Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine Department of Internal Medicine, Wakakusa-Tatsuma Rehabilitation Hospital

Abstract

Brain (or B-type) natriuretic peptide (BNP) is a cardiac hormone produced in the heart and an established biochemical marker for heart failure (HF) because the level in plasma increases in proportion to disease severity. Recently, the diversity of BNP molecular forms in the peripheral circulation, which includes mature BNP (BNP_1-32) and its metabolites (BNP_3-32, BNP_4-32, and BNP_5-32), was demonstrated. Moreover, studies showed that unprocessed BNP prohormone (proBNP) is also secreted from the heart, and its secretion is increased in patients with HF. Interestingly, BNP_1-32, its metabolites, and proBNP are all detected as immunoreactive BNP by the currently available BNP assay system. Current N-terminal proBNP (NT-proBNP) assay systems also can react to both NT-proBNP and proBNP. In addition, the N-terminal region of proBNP and NT-proBNP are often O-glycosylated, which may result in underestimation of total NT-proBNP level, which includes both glycosylated and non-glycosylated NT-proBNP, by the NT-proBNP assay system. More recently, we have shown that miR30-GALNT-dependent O-glycosylation in the N-terminal region of proBNP affects the processing of proBNP and contributes to its secretion from the heart. The level of proBNP relative to BNP (proBNP/BNP ratio) in the coronary sinus is higher in patients with more severe HF. The proBNP/BNP ratio and the deglycosylated NT-proBNP level may be new and clinically useful biomarkers of HF.

Journal

• Circulation Journal

  Circulation Journal 82 (10), 2455-2461, 2018-09-25

  The Japanese Circulation Society

Keywords

• BNP
• Heart failure
• NT-proBNP
• <i>O</i>-glycosylation
• proBNP

Details

• CRID: 1390282763049539968
• NII Article ID: 130007489414
• NII Book ID: AA11591968
• DOI: 10.1253/circj.cj-18-0824
• ISSN: 13474820
• ISSN: 13469843
• NDL BIB ID: 029230010
• PubMed: 30135320
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I029230010
• Web Site: https://www.jstage.jst.go.jp/article/circj/82/10/82_CJ-18-0824/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2019149417
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed