Endothelial Dysfunction Is Associated with Cognitive Impairment of Elderly Cardiovascular Disease Patients
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- Fujiyoshi Kazuhiro
- Kitasato University Graduate School of Medical Sciences
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- Yamaoka-Tojo Minako
- Department of Rehabilitation, Kitasato University School of Allied Health Sciences
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- Minami Yoshiyasu
- Department of Cardiovascular Medicine, Kitasato University School of Medicine
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- Kutsuna Toshiki
- Department of Cardiac Rehabilitation, Kitasato University East Hospital
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- Obara Shinichi
- Department of Cardiac Rehabilitation, Kitasato University East Hospital
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- Kakizaki Ryota
- Kitasato University Graduate School of Medical Sciences
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- Nemoto Teruyoshi
- Kitasato University Graduate School of Medical Sciences
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- Hashimoto Takuya
- Kitasato University Graduate School of Medical Sciences
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- Namba Sayaka
- Department of Cardiovascular Medicine, Kitasato University School of Medicine
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- Shimohama Takao
- Department of Cardiovascular Medicine, Kitasato University School of Medicine
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- Tojo Taiki
- Department of Cardiovascular Medicine, Kitasato University School of Medicine
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- Ako Junya
- Department of Cardiovascular Medicine, Kitasato University School of Medicine
Bibliographic Information
- Other Title
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- A Reactive Hyperemia-Peripheral Arterial Tonometry Study
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Abstract
<p>Cognitive impairment is frequently represented in elderly patients with cardiovascular disease (CVD); yet, the mechanism is uncertain. Recent studies have suggested the association between the vascular endothelial dysfunction and cognitive impairment. The aim of this study was to clarify the association between endothelial dysfunction and cognitive impairment in elderly patients with CVD.</p><p>A total of 80 elderly patients (> 70 years old) with CVD were included. Patients who had already pharmacologically intervened for cognitive impairment were excluded. The endothelial dysfunction was assessed by the reactive hyperemia-peripheral arterial tonometry (RH-PAT). Cognitive impairment was diagnosed by the Mini-mental state examination.</p><p>The RH-PAT index was significantly lower in cognitive impairment (median 1.60 [interquartile range (IQR) 1.34 to 1.89], n = 51) as compared with non-cognitive impairment (median 1.75 [IQR 1.55 to 2.30], n = 29, P = 0.005). By a multivariate analysis, the RH-PAT index was independently associated with cognitive impairment (odds ratio: 0.89; 95% confidence interval: 0.81 to 0.97; per 0.1, P = 0.044). In the receiver-operating characteristic analysis, the best cut-off of the RH-PAT index to identify cognitive impairment was 1.65 (area under the curve 0.67; P = 0.011) with limited the sensitivity (63%) and specificity (66%).</p><p>A lower RH-PAT index was significantly associated with the presence of cognitive impairment in elderly CVD patients. Further studies are required to clarify the mechanism and the causal relationship between the endothelial dysfunction and cognitive impairment in patients with CVD.</p>
Journal
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- International Heart Journal
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International Heart Journal 59 (5), 1034-1040, 2018-09-01
International Heart Journal Association
