A Multiple Biomarker Approach in Patients with Cardiac Sarcoidosis

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Author(s)

    • Kiko Takatoyo
    • Department of Cardiovascular Medicine, Fukushima Medical University
    • Ishida Takafumi
    • Department of Cardiovascular Medicine, Fukushima Medical University
    • Yoshihisa Akiomi
    • Department of Cardiovascular Medicine, Fukushima Medical University|Department of Advanced Cardiac Therapeutics, Fukushima Medical University
    • Kanno Yuki
    • Department of Cardiovascular Medicine, Fukushima Medical University
    • Abe Satoshi
    • Department of Cardiovascular Medicine, Fukushima Medical University
    • Misaka Tomofumi
    • Department of Cardiovascular Medicine, Fukushima Medical University

Abstract

<p>Sarcoidosis is a systemic granulomatous disease including heart (cardiac sarcoidosis, CS). It has recently been reported that isolated CS, which presenting primarily cardiac symptoms without clinical evidence of sarcoid involvement in other organs. Diagnostic and prognostic biomarkers of CS, especially in isolated CS, have not yet been established.</p><p>We studied plasma levels of angiotensin-converting enzyme (ACE), soluble interleukin-2 receptor (sIL-2R), B-type natriuretic peptide (BNP) and cardiac troponin I (cTnI) in consecutive 172 patients with diagnosed sarcoidosis. We compared these markers between non-cardiac sarcoidosis (non-CS, <i>n</i> = 123, 71.5%) and CS patients (<i>n</i> = 49, 28.5%), including non-isolated CS (<i>n</i> = 30, 17.4%) and isolated CS (<i>n</i> = 19, 11.1%). ROC analysis revealed that BNP identified CS with AUC of 0.85 (<i>P</i> < 0.01) in sarcoidosis patients. In addition, ACE and sIL-2R levels were significantly higher in non-isolated CS than in isolated CS (<i>P</i> < 0.05). Furthermore, in the Cox proportional hazard analysis, cTnI, but not ACE, IL2R or BNP, was a predictor of fatal arrhythmia in sarcoidosis patients (HR 2.418, <i>P</i> = 0.003).</p><p>Higher ACE and sIL2-R are associated with systemic lesions, whereas BNP is a useful marker for detecting cardiac involvement in sarcoidosis patients. cTnI is a predictor of fatal arrhythmia in CS patients. A multiple biomarker approach supports comprehensive management of sarcoidosis.</p>

Journal

  • International Heart Journal

    International Heart Journal 59(5), 996-1001, 2018

    International Heart Journal Association

Codes

  • NII Article ID (NAID)
    130007490569
  • Text Lang
    ENG
  • ISSN
    1349-2365
  • Data Source
    J-STAGE 
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