Cardioprotective Effects of High-Density Lipoprotein Beyond its Anti-Atherogenic Action

DOI HANDLE Web Site PubMed 3 Citations 76 References Open Access
  • Nagao Manabu
    Division of Cardiovascular Medicine, Kobe University Graduate School of Medicine
  • Nakajima Hideto
    Division of Cardiovascular Medicine, Kobe University Graduate School of Medicine
  • Toh Ryuji
    Division of Evidence-Based Laboratory Medicine, Kobe University Graduate School of Medicine
  • Hirata Ken-ichi
    Division of Cardiovascular Medicine, Kobe University Graduate School of Medicine
  • Ishida Tatsuro
    Division of Cardiovascular Medicine, Kobe University Graduate School of Medicine

Abstract

<p>High-density lipoprotein cholesterol (HDL-C) has been identified as a powerful independent negative predictor of cardiovascular disease. The beneficial effect of HDL is largely attributable to its key role in reverse cholesterol transport, whereby excess cholesterol in the peripheral tissues is transported to the liver, reducing the atherosclerotic burden. However, mounting evidence indicates that HDL also has pleiotropic properties, such as anti-inflammatory, anti-oxidative, and vasodilatory properties, which may contribute in reducing the incidence of heart failure. Actually, previous data from clinical and experimental studies have suggested that HDL exerts cardioprotective effects irrespective of the presence/absence of coronary artery disease. This review summarizes the currently available evidence regarding beneficial effects of HDL on the heart beyond its anti-atherogenic property. Understanding the mechanisms of cardiac protection by HDL will provide new insight into the underlying mechanism and therapeutic strategy for heart failure.</p>

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