特集 ここまで明らかになったω3脂肪酸 「脳の発生・発達におけるDHAの役割」 The role of docosahexaenoic acid in brain development

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著者

    • 酒寄 信幸 Sakayori Nobuyuki
    • 福島県立医科大学医学部附属生体情報伝達研究所生体機能研究部門 Department of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University
    • 大隅 典子 Osumi Noriko
    • 東北大学大学院医学系研究科発生発達神経科学分野 Department of Developmental Neuroscience, Center for Neuroscience, United Centers for Advanced Research and Translational Medicine, Tohoku University School of Medicine

抄録

Docosahexaenoic acid (DHA) is the principal -3 polyunsaturated fatty acids (PUFAs) in the brain, and it is essential for proper brain development. -3 PUFAs are not synthesized de novo in mammals, and thus they must be obtained from diets. Revealing the role of DHA in brain development is scientifically and socially important because intake of fishes, which are abundant in -3 PUFAs, has recently been decreased in many countries, including Japan. Previous in vitro studies have revealed the role of DHA in neural stem cells (NSCs); DHA modulates proliferation and neuronal differentiation of NSCs. In evaluation of in vivo roles of DHA, the balance of -3/-6 PUFAs must be considered due to the competition between these two classes of PUFAs for their synthesis, metabolism, and transport. Recently, we have reported the impact of maternal consumption of an -3-poor/-6-rich diet, a widely spread nutrition style in the world, on offspring's brain development in mice. We found that epoxy metabolites of DHA and arachidonic acid (an -6 PUFA) regulated the neurogenic-to-gliogenic fate transition of NSCs, and consequently they affected brain development. In the present review, we summarize the roles of DHA and its metabolites in NSCs and in brain development.

収録刊行物

  • ビタミン

    ビタミン 91(9), 547-554, 2017

    公益社団法人 日本ビタミン学会

各種コード

  • NII論文ID(NAID)
    130007493224
  • NII書誌ID(NCID)
    AN00207833
  • 本文言語コード
    JPN
  • ISSN
    0006-386X
  • NDL 記事登録ID
    028552648
  • NDL 請求記号
    Z19-36
  • データ提供元
    NDL  J-STAGE 
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