AMPK as a Metabolic Intersection between Diet and Physical Exercise

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  • Miyamoto Licht
    Department of Medical Pharmacology, Institute of Biomedical Sciences, Graduate School of Tokushima University

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Other Title
  • 身体運動と食をつなぐ生体内エネルギー調節の分子機構
  • Symposium Review 身体運動と食をつなぐ生体内エネルギー調節の分子機構
  • Symposium Review シンタイ ウンドウ ト ショク オ ツナグ セイタイナイ エネルギー チョウセツ ノ ブンシ キコウ

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Abstract

<p>　Physical exercise is well known to be beneficial to our health. Therapeutic exercise is widely applicable to metabolic disorders, including obesity and diabetes. In addition, recent studies have suggested its potential benefit in the treatment of more various diseases such as mental disorders and cancer. 5′AMP-activated protein kinase (AMPK), which is an intracellular central metabolic sensor as well as a regulator, has been demonstrated to play significant roles in the contracting skeletal muscles, suggesting that AMPK should be one of the key molecules mediating metabolic effects during physical exercise. Therefore, AMPK is a desirable therapeutic target for drug discovery. In the symposium S41 held in the 137th Annual Meeting of the Pharmaceutical Society of Japan, our data on the molecular mechanisms of isoform-specific postprandial suppression of AMPK activity were shared, and we discussed potential roles of AMPK as an intersection where metabolic signals by physical exercise and feeding status crosstalk. Here, I would like to introduce basic knowledge related to AMPK and recent findings regarding how AMPK activity is regulated in response to physiological and pharmacological stimulation.</p>

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 138 (10), 1291-1296, 2018-10-01

    The Pharmaceutical Society of Japan

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