Regulation Mechanism of Endocytosis of NKCC2 by Moesin

DOI Web Site Web Site

Bibliographic Information

Other Title
  • 膜輸送タンパク質NKCC2のエンドサイトーシスにおける Moesin の制御機構
  • マク ユソウ タンパクシツ NKCC2 ノ エンドサイトーシス ニ オケル Moesin ノ セイギョ キコウ

Search this article

Abstract

Tubular reabsorption of electrolytes in the kidney is an essential function in regulating fluid balance in the body. Na+–K+–2Cl– cotransporter type 2 (NKCC2) is specifically expressed in luminal cell surface of the thick ascending limb of the loop of Henle and the macula densa. The reabsorption of NKCC2 plays important roles in regulating fluid balance and glomerular filtration rate (GFR). In general, luminal surface expression level of NKCC2 is regulated by intracellular membrane trafficking involving exocytosis and endocytosis. It is well known that exocytosis of NKCC2 is promoted by the cAMP/PKA pathway via some hormone stimulation. On the other hand, the molecular mechanisms of endocytosis of NKCC2 are not clear. In this review, I will discuss the roles of moesin, which was reported as a NKCC2–binding protein, in the regulation of endocytosis of NKCC2 and renal function in vivo by using moesin–null (Msn–/y) mice.

Journal

  • MEMBRANE

    MEMBRANE 43 (5), 199-205, 2018

    THE MEMBRANE SOCIETY OF JAPAN

Related Projects

See more

Keywords

Details 詳細情報について

Report a problem

Back to top