Sleep Disturbance and Hyperactivity Detected by Actigraphy in Rats with Allergic Rhinitis or Attention-Deficit Hyperactivity Disorder
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- Suzuki Motohiko
- Department of Otorhinolaryngology, Nagoya City University
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- Nakayama Meiho
- Department of Otorhinolaryngology, Nagoya City University Good Sleep Center, Nagoya City University Hospital
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- Ando Kayoko Bhardwaj
- Good Sleep Center, Nagoya City University Hospital
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- Arima Sachie
- Department of Otorhinolaryngology, Nagoya City University Good Sleep Center, Nagoya City University Hospital
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- Nakamura Yoshihisa
- Department of Otorhinolaryngology, Nagoya City University
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- Yokota Makoto
- Department of Otorhinolaryngology, Nagoya City University
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- Murakami Shingo
- Department of Otorhinolaryngology, Nagoya City University
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Abstract
<p>Actigraphy is an easy and noninvasive method used to monitor human ultradian cycles. However, to our knowledge, it has been not applied to experiments with rodents. Therefore, using actigraphy, we assessed the ultradian cycles and behavior of rats. Rats with or without allergic rhinitis wore an actigraphy device, and triaxial acceleration was recorded. The counts that represent physical activity were lower from 8:00 to 20:00 than those from 20:00 to 8:00 in control rats, suggesting that their sleep phase was from 8:00 to 20:00 and their awake phase from 20:00 to 8:00. The counts from 8:00 to 10:00 were significantly higher in allergic rhinitis rats than in control rats (p < 0.01), suggesting the presence of difficulty with sleep induction in rats with allergic rhinitis. The counts from 18:00 to 20:00 were also significantly higher in allergic rhinitis rats than in control rats (p < 0.05), suggesting the presence of early awakening in rats with allergic rhinitis. Moreover, the counts were significantly higher in allergic rhinitis rats than in control rats from 20:00 to 8:00. These results suggest that rats with allergic rhinitis experienced hyperactivity disorder during the daytime. Additionally, hyperreactivity and difficulty with sleep induction were observed in 6-hydroxydopamine-lesioned rats, an animal model of attention-deficit hyperactivity disorder. This study shows for the first time that actigraphy can be successfully used for behavioral analysis in rodents. These rat models could be useful for analyzing the mechanisms involved in sleep disturbances and hyperactivity disorder.</p>
Journal
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- The Tohoku Journal of Experimental Medicine
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The Tohoku Journal of Experimental Medicine 246 (2), 65-71, 2018
Tohoku University Medical Press