Regulation of Trafficking of Glucose Transporter by Cardiac Glycosides in Hepatocellular Carcinoma Cells

• Fujii Takuto

  Department of Pharmaceutical Physiology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama

• Sakai Hideki

  Department of Pharmaceutical Physiology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama

Bibliographic Information

Other Title

• 強心配糖体による肝がん細胞のグルコーストランスポーターの トラフィッキング制御
• キョウシンハイトウタイ ニ ヨル カンガン サイボウ ノ グルコーストランスポーター ノ トラフィッキング セイギョ

Abstract

Cancer cells generally display glucose metabolic reprograming characterized by an increased rate of aerobic glycolysis even under normoxic conditions (also known as Warburg effect). To achieve the rapid proliferation of cancer cells in hypoxic environment, expression level of facilitative glucose transporter GLUT1 is elevated in several cancer cells including hepatocellular carcinoma. Recently, we found that cardiac glycosides, specific inhibitors of Na+, K+– ATPase, induce GLUT1 endocytosis and dramatically suppress the glucose uptake of human hepatocellular carcinoma cells. In this review, we introduce our recent findings concerning inhibitory mechanism of GLUT1 induced by cardiac glycosides in human cancer cells.

Journal

• MEMBRANE

  MEMBRANE 43 (5), 194-198, 2018

  THE MEMBRANE SOCIETY OF JAPAN

Keywords

• cancer cell
• cardiac glycoside
• glucose transporter
• Na⁺, K⁺-ATPase
• Warburg effect

Details

• CRID: 1390564238027394304
• NII Article ID: 130007495165
• NII Book ID: AN0023215X
• DOI: 10.5360/membrane.43.194
• ISSN: 18846440
• ISSN: 03851036
• NDL BIB ID: 030039239
• Web Site: http://id.ndl.go.jp/bib/030039239
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I030039239
• Web Site: https://www.jstage.jst.go.jp/article/membrane/43/5/43_194/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2019104076
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed