Methanol extraction fraction from Citrus Sudachi peel exerts lipid reducing effects in cultured cells

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  • Xu Wenting
    Department of Medical Pharmacology, Institute of Biomedical Sciences, Graduate School of Tokushima University
  • Miyamoto Licht
    Department of Medical Pharmacology, Institute of Biomedical Sciences, Graduate School of Tokushima University
  • Aihara Haruna
    Department of Medical Pharmacology, Institute of Biomedical Sciences, Graduate School of Tokushima University
  • Yamaoka Tomomi
    Department of Medical Pharmacology, Institute of Biomedical Sciences, Graduate School of Tokushima University
  • Tanaka Naonobu
  • Tsuchihashi Yuki
    Department of Medical Pharmacology, Institute of Biomedical Sciences, Graduate School of Tokushima University
  • Ikeda Yasumasa
    Department of Pharmacology, Institute of Biomedical Sciences, Graduate School of Tokushima University
  • Tamaki Toshiaki
    Department of Pharmacology, Institute of Biomedical Sciences, Graduate School of Tokushima University
  • Kashiwada Yoshiki
    Department of Pharmacognosy, Institute of Biomedical Sciences, Graduate School of Tokushima University
  • Tsuchiya Koichiro
    Department of Medical Pharmacology, Institute of Biomedical Sciences, Graduate School of Tokushima University

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Abstract

<p>Ectopic fat accumulation is associated with insulin resistance and type 2 diabetes mellitus. Citrus sudachi is an evergreen tree that is found mainly in Tokushima Prefecture in Japan. Previously, it was demonstrated that Citrus sudachi could inhibit the rising trend of blood glucose and fatty acid in human subjects. In the current study, we illustrated the function of methanol extracts from sudachi peel and investigated the mechanism of this effect. We got the five kinds of methanol extracts by using diaion HP‐20, and those were named by hydrophobicity from M‐F1 to M‐F5. Among the 5 kinds of sudachi methanol extracts, only M‐F4 significantly decreased the intracellular triglyceride of C2C12 cells. It augmented the AMPK activity and increased the transcription of PPARα and its downstream targets CPT‐1b and UCP2. In conclusion, M‐F4 improved the lipid metabolism possibly through AMPK, PPARα and their downstream targets like CPT‐1b and UCP2. Furthermore, this extract may be useful for preventing obesity and diabetes related diseases. J. Med. Invest. 65:225‐230, August, 2018</p>

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