Urinary Exosomal mRNA of WT1 as Diagnostic and Prognostic Biomarker for Diabetic Nephropathy

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Author(s)

    • Abe Hideharu
    • Department of Nephrology, Institute of Biomedical Sciences, Tokushima University Graduate School
    • Tamaki Masanori
    • Department of Nephrology, Institute of Biomedical Sciences, Tokushima University Graduate School
    • Kishi Fumi
    • Department of Nephrology, Institute of Biomedical Sciences, Tokushima University Graduate School
    • Kishi Seiji
    • Department of Nephrology, Institute of Biomedical Sciences, Tokushima University Graduate School
    • Murakami Taichi
    • Department of Nephrology, Institute of Biomedical Sciences, Tokushima University Graduate School
    • Nagai Kojiro
    • Department of Nephrology, Institute of Biomedical Sciences, Tokushima University Graduate School
    • Doi Toshio
    • Department of Nephrology, Institute of Biomedical Sciences, Tokushima University Graduate School
    • Sakurai Akiko
    • Department of Nephrology, Institute of Biomedical Sciences, Tokushima University Graduate School
    • Ono Hiroyuki
    • Department of Nephrology, Institute of Biomedical Sciences, Tokushima University Graduate School
    • Hayashi Sanae
    • Department of Nephrology, Institute of Biomedical Sciences, Tokushima University Graduate School
    • Yoshimoto Sakiya
    • Department of Nephrology, Institute of Biomedical Sciences, Tokushima University Graduate School
    • Ochi Arisa
    • Department of Nephrology, Institute of Biomedical Sciences, Tokushima University Graduate School
    • Ueda Sayo
    • Department of Nephrology, Institute of Biomedical Sciences, Tokushima University Graduate School
    • Nishimura Kenji
    • Department of Nephrology, Institute of Biomedical Sciences, Tokushima University Graduate School
    • Shibata Eriko
    • Department of Nephrology, Institute of Biomedical Sciences, Tokushima University Graduate School

Abstract

<p>Diabetic nephropathy (DN) is the major cause of end‐stage renal failure and is associated with increased morbidity and mortality as compared to other causes of renal disease. Albuminuria is often the first clinical indicator of the presence of DN. However, albuminuria or proteinuria is a common symptom in patients with various renal disorders. Therefore, specific biomarkers for the diagnosis of DN are required. A primary hallmark of DN is the progressive damage and death of glomerular podocytes, resulting in the leaking of proteins into the urine. Urinary exosomes released by podocytes are microvesicles containing information of the originated cells. Podocyte‐derived signal transduction factors (PDSTFs) are good candidates to assess podocyte injuries. The profile of PDSTFs in urinary exosomes from patients with DN is different from that from patients with minimal change nehrotic syndrome. In addition, PDSTFs molecules in exosomes were derived from primary murine podocytes under high glucose conditions. Among PDSTFs in urinary exosomes, Wilms tumor 1 (WT1) levels reflected damage of diabetic glomeruli in the patients. Urinary exosomal WT1 can predict the decline in eGFR for the following several years. In conclusion, urinary exosomal WT1 is a useful biomarker to improve risk stratification in patients with DN. J. Med. Invest. 65:208‐215, August, 2018</p>

Journal

  • The Journal of Medical Investigation

    The Journal of Medical Investigation 65(3.4), 208-215, 2018

    Faculty of Medicine Tokushima University

Codes

  • NII Article ID (NAID)
    130007495809
  • NII NACSIS-CAT ID (NCID)
    AA12022913
  • Text Lang
    ENG
  • Article Type
    journal article
  • ISSN
    1343-1420
  • Data Source
    IR  J-STAGE 
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