Assessment of renal function in Japanese children with malignancies using serum cystatin C

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Author(s)

    • Nakamura Nami
    • Department of Pediatrics, the University of Tokushima Graduate School|Department of Pediatrics, The Tsurugi Town Handa Hospital
    • Okamura Kazumi
    • Department of Pediatrics, the University of Tokushima Graduate School
    • Kagami Shoji
    • Department of Pediatrics, the University of Tokushima Graduate School

Abstract

Several factors besides renal function influence serum cystatin C (CysC) levels. The present study evaluates the value of serum CysC and the equation for CysC based estimated glomerular filtration rate (CysC-eGFR) for Japanese children with malignancies.We collected information at 36 time points from 13 patients aged ≤ 17 years with malignancies. We assessed tumor activity, cell recovery phase after chemotherapy, neutropenia phase, inflammation response and medication with granulocyte-colony stimulating factor, steroid, and levothyroxine as risk factors associated with serum CysC levels. Although no 24-h creatinine clearance (CCr) data collected at 36 time points indicated renal dysfunction, serum CysC levels were above and below the reference values at four and five time points, respectively. The frequency of elevated serum CysC levels was higher in patients without therapy or with stable or progressive disease than among those with a complete or partial response (p = 0.0046). The correlation coefficient between CCr and CysC-eGFR was 0.355 (p = 0.054), but this improved to 0.663 (p = 0.0010) when restricted to patients with a complete or partial response. Levels of serum CysC might become elevated regardless of renal function, and CysC-eGFR might become unpredictable during the active phase of tumors.

<p>Several factors besides renal function influence serum cystatin C (CysC) levels. The present study evaluates the value of serum CysC and the equation for CysC based estimated glomerular filtration rate (CysC‐eGFR) for Japanese children with malignancies. We collected information at 36 time points from 13 patients aged ≤ 17 years with malignancies. We assessed tumor activity, cell recovery phase after chemotherapy, neutropenia phase, inflammation response and medication with granulocyte‐colony stimulating factor, steroid, and levothyroxine as risk factors associated with serum CysC levels. Although no 24‐h creatinine clearance (CCr) data collected at 36 time points indicated renal dysfunction, serum CysC levels were above and below the reference values at four and five time points, respectively. The frequency of elevated serum CysC levels was higher in patients without therapy or with stable or progressive disease than among those with a complete or partial response (<i>p</i> = 0.0046). The correlation coefficient between CCr and CysC‐eGFR was 0.355 (<i>p</i> = 0.054), but this improved to 0.663 (<i>p</i> = 0.0010) when restricted to patients with a complete or partial response. Levels of serum CysC might become elevated regardless of renal function, and CysC‐eGFR might become unpredictable during the active phase of tumors. J. Med. Invest. 65:231‐235, August, 2018</p>

Journal

  • The Journal of Medical Investigation

    The Journal of Medical Investigation 65(3.4), 231-235, 2018

    Faculty of Medicine Tokushima University

Codes

  • NII Article ID (NAID)
    130007495847
  • NII NACSIS-CAT ID (NCID)
    AA12022913
  • Text Lang
    ENG
  • Article Type
    journal article
  • ISSN
    1343-1420
  • Data Source
    IR  J-STAGE 
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