Diagnostic Performance of Arterial Spin Labeling for Grading Nonenhancing Astrocytic Tumors
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- Khashbat Delgerdalai
- Departments of Radiology and Radiation Oncology, Institute of Biomedical Sciences, Tokushima University Graduate School
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- Harada Masafumi
- Departments of Radiology and Radiation Oncology, Institute of Biomedical Sciences, Tokushima University Graduate School
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- Abe Takashi
- Departments of Radiology and Radiation Oncology, Institute of Biomedical Sciences, Tokushima University Graduate School
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- Ganbold Mungunbagana
- Departments of Radiology and Radiation Oncology, Institute of Biomedical Sciences, Tokushima University Graduate School
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- Iwamoto Seiji
- Departments of Radiology and Radiation Oncology, Institute of Biomedical Sciences, Tokushima University Graduate School
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- Uyama Naoto
- Departments of Radiology and Radiation Oncology, Institute of Biomedical Sciences, Tokushima University Graduate School
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- Irahara Saho
- Departments of Radiology and Radiation Oncology, Institute of Biomedical Sciences, Tokushima University Graduate School
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- Otomi Youichi
- Departments of Radiology and Radiation Oncology, Institute of Biomedical Sciences, Tokushima University Graduate School
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- Kageji Teruyoshi
- Department of Neurosurgery, Institute of Biomedical Sciences, Tokushima University Graduate School
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- Nagahiro Shinji
- Department of Neurosurgery, Institute of Biomedical Sciences, Tokushima University Graduate School
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抄録
<p>Purpose: We evaluated the utility of arterial spin labeling (ASL) imaging of tumor blood flow (TBF) for grading non-enhancing astrocytic tumors.</p><p>Materials and Methods: Thirteen non-enhancing astrocytomas were divided into high-grade (n = 7) and low-grade (n = 6) groups. Both ASL and conventional sequences were acquired using the same magnetic resonance machine. Intratumoral absolute maximum TBF (TBFmax), absolute mean TBF (TBFmean), and corresponding values normalized to cerebral blood flow (TBFmax and TBFmean ratios) were measured. The Mann-Whitney U test and receiver operating characteristic (ROC) curve analysis were used to assess the accuracy of TBF variables for tumor grading.</p><p>Results: Compared with low-grade astrocytoma, high-grade astrocytoma exhibited significantly greater absolute TBFmax (90.93 ± 24.96 vs 46.94 ± 20.97 ml/100 g/min, P < 0.001), TBFmean (58.75 ± 19.89 vs 31.16 ± 17.63 ml/100 g/min, P < 0.001), TBFmax ratio (3.34 ± 1.22 vs 1.35 ± 0.5, P < 0.001), and TBFmean ratio (2.15 ± 0.94 vs 0.88 ± 0.41, P < 0.001). The TBFmax ratio yielded the highest diagnostic accuracy (sensitivity 100%, specificity 86.3%), while absolute TBFmean yielded the lowest accuracy (sensitivity 85.7%, specificity 70.1%) by ROC analysis.</p><p>Conclusion: Parameters from ASL perfusion imaging, particularly TBFmax ratio, may be useful for distinguishing high-grade from low-grade astrocytoma in cases with equivocal conventional MRI findings.</p>
収録刊行物
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- Magnetic Resonance in Medical Sciences
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Magnetic Resonance in Medical Sciences 17 (4), 277-282, 2018
日本磁気共鳴医学会