Lipidomic Profiling on Oxidized Phospholipids in Type 2 Diabetes Mellitus Model Zebrafish
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- CHEN Zhen
- Faculty of Health Sciences, Hokkaido University
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- ZANG Liqing
- Graduate School of Regional Innovation Studies, Mie University
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- WU Yue
- Faculty of Health Sciences, Hokkaido University
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- NAKAYAMA Hiroko
- Graduate School of Regional Innovation Studies, Mie University
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- SHIMADA Yasuhito
- Department of Integrative Pharmacology, Graduate School of Medicine, Mie University Mie University Zebrafish Drug Screening Center
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- SHRESTHA Rojeet
- Faculty of Health Sciences, Hokkaido University
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- ZHAO Yaoyao
- Faculty of Health Sciences, Hokkaido University
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- MIURA Yusuke
- Faculty of Health Sciences, Hokkaido University
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- CHIBA Hitoshi
- Department of Nutrition, Sapporo University of Health Sciences
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- HUI Shu-Ping
- Faculty of Health Sciences, Hokkaido University
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- NISHIMURA Norihiro
- Graduate School of Regional Innovation Studies, Mie University
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Abstract
<p>Type 2 diabetes mellitus is a serious metabolic disorder in the world. Oxidative stress, as a key role on the pathogenesis of diabetes, also results in the oxidation of phospholipids. However, studies on phospholipid oxidation in diabetes, especially directly focusing on oxidized and degraded phospholipid species, are quite limited. In this study, phospholipid profiles of diabetic zebrafish plasma were characterized by LC-HRMS and MS/MS, and the total amounts of each lipid class were compared. Furthermore, the key molecular species as biomarkers in distinguishing control and diabetic samples were investigated by orthogonal partial least squares discriminant analysis. Among the identified 114 phospholipid species in total, there were 11 hydroperoxides, 7 aldehydes, and 19 lysophospholipids found significantly elevated along with the increasing blood glucose, which were known as oxidation or degradation products. Furthermore, lysophosphatidylcholine 20:5 and lysophosphatidylcholine 22:6 were assessed as potential biomarkers in diabetic zebrafish. The current work would not only help to gain further insights into diabetes, but also contribute to find new clinical parameters for the screening of the promising antioxidant agents for its therapies.</p>
Journal
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- Analytical Sciences
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Analytical Sciences 34 (10), 1201-1208, 2018-10-10
The Japan Society for Analytical Chemistry
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Details 詳細情報について
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- CRID
- 1390001288081876864
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- NII Article ID
- 130007496935
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- NII Book ID
- AA10500785
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- ISSN
- 13482246
- 09106340
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- HANDLE
- 2115/72155
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- NDL BIB ID
- 029268319
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- PubMed
- 30101832
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- Web Site
- https://ndlsearch.ndl.go.jp/books/R000000004-I029268319
- https://link.springer.com/content/pdf/10.2116/analsci.18P281.pdf
- https://link.springer.com/article/10.2116/analsci.18P281/fulltext.html
- https://www.jstage.jst.go.jp/article/analsci/34/10/34_18P281/_pdf
- https://search.jamas.or.jp/link/ui/2019149556
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- Text Lang
- en
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- Data Source
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- JaLC
- IRDB
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed