Cytological findings associated with human papillomavirus infection in uterine cervical squamous lesions

• SHIMODAI Sayaka

  Department of Health Sciences, Graduate School of Medical Sciences, Kyushu University Department of Clinical Laboratory, Iizuka Hospital Department of Human Pathology, Faculty of Medicine Pathophysiology, Nihon University

• WATANABE Sumiko

  Department of Health Sciences, Faculty of Medical Sciences, Kyushu University

• KAKU Tsunehisa

  Department of Health Sciences, Faculty of Medical Sciences, Kyushu University

• KUWAOKA Isao

  Department of Clinical Laboratory, Iizuka Hospital

• SUGISHIMA Setsuo

  Department of Health Sciences, Faculty of Medical Sciences, Kyushu University

• OYA Masafumi

  Department of Pathology, Iizuka Hospital

Bibliographic Information

Other Title

• 子宮頸部扁平上皮病変における HPV (human papillomavirus) 感染と細胞像の関連性

Abstract

Objective : We sought to determine the characteristic cytological findings associated with HR-HPV infection in uterine cervical squamous lesions. Study Design : We examined 54 cervical smears obtained from 54 patients : the HR-HPV (+) group (n=30) and the HR-HPV (−) group (n=24). We counted the number of compression-positive multinucleated cells and number of koilocytes, and evaluated the stainability of nuclear chromatin and calculated the RD values using a digital imaging analysis software. Results : A significantly larger number of binucleated cells with compression was observed in the HR-HPV (+) group as compared to the HR-HPV (−) group. No significant inter group difference was observed in the numbers of binucleated cells without compression, multinucleated cells, or koilocytes. Regarding nuclear chromatin, although no significant inter group difference was observed in the stainability, the highest staining intensity tended to be localized at the nuclear periphery in the HR-HPV (+) group. Conclusion : Our results indicated an association between HR-HPV infection and (1) the appearance of binucleated cells with compression and (2) localization of the nuclear chromatin at the nuclear periphery, as shown by the RD values.

Journal

• The Journal of the Japanese Society of Clinical Cytology

  The Journal of the Japanese Society of Clinical Cytology 57 (5), 251-258, 2018

  The Japanese Society of Clinical Cytology

Keywords

• Uterine cervical squamous lesions
• RD value
• Infection with high-risk human papillomavirus
• Binucleated cell with compression
• Nuclear chromatin

Details

• CRID: 1390282763066269056
• NII Article ID: 130007506203
• DOI: 10.5795/jjscc.57.251
• ISSN: 18827233
• ISSN: 03871193
• Web Site: https://www.jstage.jst.go.jp/article/jjscc/57/5/57_251/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2019019459
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed