Electrochemically Modulated Surface-Enhanced Raman Spectra of Aminoglutethimide (AGI) on a Ag-Sputtered Electrode

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<jats:title>Abstract</jats:title> <jats:p>We have investigated the quantitative detection of aminoglutethimide (AGI) based on its adsorption on a SERS-active screen-printed electrode employing Electrochemical Surface-Enhanced Raman Spectroscopy (EC-SERS) technology. EC-SERS spectra of AGI molecules exhibited different adsorption mode onto the substrate with different potentials applied. When the applied potential reaches −400 mV, the intensities of the EC-SERS peaks provided by both aniline moiety and glutarimide moiety were significantly enhanced, which suggests the bidentate interaction of AGI molecule with the substrate. The peak of 1147 cm−1 showed the strongest intensity among the wavenumbers, with peak intensity over 30 times stronger than that of the standard SERS signal. A linear dependence occurred in the range of 1 × 10−5 M to 2 × 10−7 M. The limit of detection (LOD) is 40 ng/mL and the R squared of the linear curve was 0.98. This work was completed on a coin-sized chip using low sample volume (30 µL) only. Trace detection of this drug using this technique would be useful for the deterrence and prevention of dopant usage and other point-of-care diagnostics (POCD).</jats:p>

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