Nodal Pleomorphic B Cell Lymphoma at the Earliest Stage of Tumor Development in a Cow
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- SOCHI Yuichiro
- Miyagi Prefectural Sendai Livestock Hygiene Center
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- TAKAMORI Hironori
- Miyagi Prefectural Sendai Livestock Hygiene Center
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- SATO Hidetoshi
- Miyagi Prefectural Livestock Experiment Station
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- NUMABE Takashi
- Miyagi Prefectural Livestock Experiment Station
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- HAGIWARA Akiyo
- Saitama Prefecture Meat Inspection Center
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- ISHIKAWA Yoshiharu
- Hokkaido Research Station, National Institute of Animal Health, National Agriculture and Food Research Organization
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- KADOTA Koichi
- Hokkaido Research Station, National Institute of Animal Health, National Agriculture and Food Research Organization
抄録
<p>Pleomorphic B cell lymphoma was detected in a small number of lymph nodes in an 8-year-old Holstein cow with persistent lymphocytosis associated with bovine leukemia virus (BLV). Necropsy showed enlargement of the left superficial inguinal and right deep inguinal lymph nodes. Large numbers of BLV copies were detected by real-time polymerase chain reaction analysis in the enlarged nodes, whereas little BLV was found in normal-sized lymph nodes. Histologically, the enlarged lymph nodes were occupied by diffusely growing pleomorphic cells. In a few other lymph nodes, in contrast, extensive areas of neoplastic mantle cells showing a transition to more malignant pleomorphic cells were observed. These virological and histological findings indicate that large numbers of viral copies may be closely related to transformation from neoplastic mantle cells to pleomorphic lymphoma cells. The current study supports the view that nodal pleomorphic B cell lymphoma is of mantle cell origin.</p>
収録刊行物
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- Japan Agricultural Research Quarterly: JARQ
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Japan Agricultural Research Quarterly: JARQ 52 (4), 353-358, 2018-10-01
国立研究開発法人 国際農林水産業研究センター
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詳細情報 詳細情報について
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- CRID
- 1390001288092731136
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- NII論文ID
- 130007518946
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- ISSN
- 21858896
- 00213551
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可