<i>C</i>-Mannosylation: Previous Studies and Future Research Perspectives
-
- Niwa Yuki
- Department of Applied Chemistry, Faculty of Science and Technology, Keio University
-
- Simizu Siro
- Department of Applied Chemistry, Faculty of Science and Technology, Keio University
Bibliographic Information
- Other Title
-
- C-Mannosylation : Previous Studies and Future Research Perspectives
- C-mannnosylation: previous studies and future research perspectives
Search this article
Abstract
<p>C-linked glycosylation, one of the protein glycosylations, is a unique type of glycosylation in which an α-mannose is attached to the indole C2 carbon of a tryptophan residue via a C–C linkage and is so named C-mannosylation. C-mannosylation is enzymatically catalyzed in the endoplasmic reticulum (ER) lumen, and the N-terminal side Trp residue of the consensus amino acid sequence Trp-Xaa-Xaa-Trp/Cys (Xaa represents any amino acid) is often C-mannosylated. It has been reported that about 30 proteins are C-mannosylated, and the functions of C-mannosylation are becoming clear. In 2013, C. elegans dumpy-19 (dpy-19) was identified as a C-mannosyltransferase, and we revealed that DPY19L3, one of the human homologs of dpy-19, has similar activity in 2016. In this review, we describe previous studies about C-mannosylation, including our results and future research perspectives.</p>
Journal
-
- Trends in Glycoscience and Glycotechnology
-
Trends in Glycoscience and Glycotechnology 30 (177), E231-E238, 2018-11-25
FCCA(Forum: Carbohydrates Coming of Age)
- Tweet
Keywords
Details 詳細情報について
-
- CRID
- 1390845713024971392
-
- NII Article ID
- 40021833645
- 130007521332
-
- NII Book ID
- AA10995236
-
- ISSN
- 18832113
- 09157352
-
- NDL BIB ID
- 029562154
-
- Text Lang
- en
-
- Data Source
-
- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
-
- Abstract License Flag
- Disallowed