子宮峡部癌の臨床病理学的特徴と Lynch 症候群との関連  [in Japanese] Clinicopathological Features of Carcinoma of the Lower Uterine Segment and Relationship with Lynch Syndrome  [in Japanese]

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Author(s)

    • 増田 健太 Masuda Kenta
    • 慶應義塾大学医学部産婦人科学教室 Department of Obstetrics and Gynecology , School of Medicine, Keio University
    • 進 伸幸 Susumu Nobuyuki
    • 慶應義塾大学医学部産婦人科学教室 Department of Obstetrics and Gynecology , School of Medicine, Keio University
    • 青木 大輔 Aoki Daisuke
    • 慶應義塾大学医学部産婦人科学教室 Department of Obstetrics and Gynecology , School of Medicine, Keio University
    • 阪埜 浩司 Banno Kouji
    • 慶應義塾大学医学部産婦人科学教室 Department of Obstetrics and Gynecology , School of Medicine, Keio University
    • 矢野倉 恵 Yanokura Megumi
    • 慶應義塾大学医学部産婦人科学教室 Department of Obstetrics and Gynecology , School of Medicine, Keio University
    • 辻 浩介 Tsuji Kosuke
    • 慶應義塾大学医学部産婦人科学教室 Department of Obstetrics and Gynecology , School of Medicine, Keio University
    • 木須 伊織 Kisu Iori
    • 慶應義塾大学医学部産婦人科学教室 Department of Obstetrics and Gynecology , School of Medicine, Keio University
    • 植木 有紗 Ueki Arisa
    • 慶應義塾大学医学部産婦人科学教室 Department of Obstetrics and Gynecology , School of Medicine, Keio University
    • 野村 弘行 Nomura Hiroyuki
    • 慶應義塾大学医学部産婦人科学教室 Department of Obstetrics and Gynecology , School of Medicine, Keio University
    • 平沢 晃 Hirasawa Akira
    • 慶應義塾大学医学部産婦人科学教室 Department of Obstetrics and Gynecology , School of Medicine, Keio University

Abstract

子宮体癌は子宮体部や底部から発生することが一般的であるが, まれに体部下部から頸部上部, つまりlower uterinesegment(LUS)もしくは峡部と呼ばれる領域から発生する子宮体癌が存在する. 子宮峡部から発生する子宮体癌(以降, 子宮峡部癌)は子宮体癌全体の3 〜3.5%とまれであり, これまで小規模の報告しか存在しない. 近年, 子宮峡部癌が遺伝性腫瘍であるLynch 症候群との関連があると報告され注目されている. 一般的な子宮体癌でのLynch 症候群の頻度は1 〜2 %といわれているが, 米国の報告によると子宮峡部癌のうち29%がLynch 症候群とされ, 高頻度にMSH2 の変異が存在するとしている. 今後わが国をはじめ, より大規模な調査において子宮峡部癌の臨床病理学的特徴やLynch 症候群との関連についてさらに検討する必要がある.

Endometrial cancer arises from the uterine body and fundus in many cases, but can also originate from the lower region of the uterine body through the upper region of the cervix. Such tumors are referred to as carcinoma of the lower uterine segment (LUS) or isthmus, and account for 3–3.5% of all cases of endometrial cancer. This relatively low incidence has permitted performance of only small-scale studies, but recently it has been reported that carcinoma of the LUS is associated with Lynch syndrome. The frequency of Lynch syndrome in cases of general endometrial cancer is 1–2%. In contrast, the frequency in patients with carcinoma of the LUS is much higher, with up to 29% of cases diagnosable with Lynch syndrome and a high frequency of MSH2 mutation found in one study. This suggests that further investigation of the clinical and pathological characteristics of carcinoma of the LUS and the association with Lynch syndrome is required through performance of a large-scale survey.

Journal

  • JOURNAL OF FAMILIAL TUMORS

    JOURNAL OF FAMILIAL TUMORS 13(1), 1-5, 2013

    The Japanese Society for Familial Tumors

Codes

  • NII Article ID (NAID)
    130007530784
  • Text Lang
    JPN
  • ISSN
    1346-1052
  • Data Source
    J-STAGE 
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