80歳一般地域住民における糖尿病と骨粗鬆症の生命予後への影響  [in Japanese] Impact of Diabetes Mellitus and Osteoporosis on Life Prognosis of 80-Year-Old Subjects in Japanese General Population  [in Japanese]

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Author(s)

    • 園木 一男 Sonoki Kazuo
    • 九州歯科大学歯学部口腔保健学科学際教育推進ユニット Unit for Promotion of Interdisciplinary Education and Research, School of Oral Health Science, Kyushu Dental University
    • 邵 仁浩 Soh Inho
    • 九州歯科大学歯学部口腔保健学科学際教育推進ユニット Unit for Promotion of Interdisciplinary Education and Research, School of Oral Health Science, Kyushu Dental University
    • 秋房 住郎 Akifusa Sumio
    • 九州歯科大学歯学部口腔保健学科学際教育推進ユニット Unit for Promotion of Interdisciplinary Education and Research, School of Oral Health Science, Kyushu Dental University
    • 福原 正代 Fukuhara Masayo
    • 九州歯科大学歯学部歯学科総合内科学分野 Division of General Internal Medicine, Department of Health Promotion, Kyushu Dental University
    • 粟野 秀慈 Awano Shuji
    • 九州歯科大学歯学部歯学科クリニカルクラークシップ開発学分野 Department of Clinical Education Development and Research, School of Dentistry, Kyushu Dental University
    • 安細 敏弘 Ansai Toshihiro
    • 九州歯科大学歯学部歯学科地域健康開発歯学分野 Division of Community Oral Health Development, Department of Health Promotion, Kyushu Dental University

Abstract

<p>日本人一般地域住民における80歳高齢者の生命予後に対する糖尿病と骨評価指数(QUS法のStiffness値)の影響を明らかにするため,福岡県北九州市近郊に住む80歳519名で12年間の生存期間と死因(全死亡,肺炎死,循環器死,悪性腫瘍死)を糖尿病なし+Stiffness高値群(I群,n=334),糖尿病なし+Stiffness低値群(II群,n=129),糖尿病あり+Stiffness高値群(III群,n=48),糖尿病あり+Stiffness低値群(IV群,n=8)の4群で比較した.Kaplan-Meier法では,全死亡,肺炎死,悪性腫瘍死において,I群に対しIV群の累積生存率が最も低かった.Cox回帰分析では,I群に対しIV群のハザード比は全死亡で3.39倍,肺炎死で6.14倍,悪性腫瘍死で5.04倍であった.骨評価指数の低下と糖尿病は独立に,そして相加的に生命予後に影響すると考えられた.</p>

<p>To investigate the influence of diabetes mellitus and the bone assessment index (a stiffness index measured by quantitative ultrasound) on mortality in 80-year-old Japanese subjects from the general population, we compared the following 4 groups: groups I (non-diabetic subjects with a high stiffness index, n=334), II (non-diabetic subjects with a low stiffness index, n=129), III (diabetic subjects with a high stiffness index, n=48), and IV (diabetic subjects with a low stiffness index, n=8). The subjects all lived in Fukuoka Prefecture and were followed-up for 12 years after the baseline examination in order to collect the date and cause of death. The cumulative survival rate during the 12-year follow-up period for all-cause mortality, pneumonia mortality, and cancer mortality in group IV was lower than that in group I. A multivariate Cox regression analysis revealed a high mortality risk in group IV compared with group I; the all-cause mortality, pneumonia mortality, and cardiovascular disease mortality during the 12-year follow-up in group IV was 3.39-fold, 6.14-fold, and 5.04-fold higher than that in group I, respectively. The presence of diabetes mellitus and a decreased stiffness index independently and additively increased the mortality risk, even in 80-year-old people.</p>

Journal

  • Journal of the Japan Diabetes Society

    Journal of the Japan Diabetes Society 61(11), 757-764, 2018

    THE JAPAN DIABETES SOCIETY

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