Impact of Diabetes Mellitus and Osteoporosis on Life Prognosis of 80-Year-Old Subjects in Japanese General Population

DOI Open Access
  • Sonoki Kazuo
    Unit for Promotion of Interdisciplinary Education and Research, School of Oral Health Science, Kyushu Dental University
  • Soh Inho
    Unit for Promotion of Interdisciplinary Education and Research, School of Oral Health Science, Kyushu Dental University
  • Hamasaki Tomoko
    Department of Nutrition, Faculty of Home Economics, Kyushu Women's University
  • Akifusa Sumio
    Unit for Promotion of Interdisciplinary Education and Research, School of Oral Health Science, Kyushu Dental University
  • Fukuhara Masayo
    Division of General Internal Medicine, Department of Health Promotion, Kyushu Dental University
  • Awano Shuji
    Department of Clinical Education Development and Research, School of Dentistry, Kyushu Dental University
  • Ansai Toshihiro
    Division of Community Oral Health Development, Department of Health Promotion, Kyushu Dental University

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Other Title
  • 80歳一般地域住民における糖尿病と骨粗鬆症の生命予後への影響

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Abstract

<p>To investigate the influence of diabetes mellitus and the bone assessment index (a stiffness index measured by quantitative ultrasound) on mortality in 80-year-old Japanese subjects from the general population, we compared the following 4 groups: groups I (non-diabetic subjects with a high stiffness index, n=334), II (non-diabetic subjects with a low stiffness index, n=129), III (diabetic subjects with a high stiffness index, n=48), and IV (diabetic subjects with a low stiffness index, n=8). The subjects all lived in Fukuoka Prefecture and were followed-up for 12 years after the baseline examination in order to collect the date and cause of death. The cumulative survival rate during the 12-year follow-up period for all-cause mortality, pneumonia mortality, and cancer mortality in group IV was lower than that in group I. A multivariate Cox regression analysis revealed a high mortality risk in group IV compared with group I; the all-cause mortality, pneumonia mortality, and cardiovascular disease mortality during the 12-year follow-up in group IV was 3.39-fold, 6.14-fold, and 5.04-fold higher than that in group I, respectively. The presence of diabetes mellitus and a decreased stiffness index independently and additively increased the mortality risk, even in 80-year-old people.</p>

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