Current Status of Azole-resistant <i>Aspergillus fumigatus</i> Isolates in East Asia:China, Japan, Korea, and Taiwan

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Abstract

<i>Aspergillus fumigatus</i> is a saprophytic fungus that is a major causative pathogen for aspergillosis. Only a few classes of antifungals are used for treating this life-threatening fungal infection. Azoles are the first-line drugs and are widely used for the management and prophylaxis of aspergillosis. An emerging issue is the increasing incidence of resistant isolates worldwide. In particular, environmentally derived tandem-repeat-type azole-resistant mutations, such as Cyp51A TR34/L98H, and Cyp51A TR46/Y121F/T289A, have emerged over the last decade. In particular, azole-resistant isolates were prevalent in clinical settings in European countries; many of the reports are from the Netherlands, UK, and Germany. In contrast, reports on azole-resistant <i>A. fumigatus</i> isolates from East Asian countries are still few and have only recently begun to increase. Herein, all literature on East Asian azole-resistant <i>A. fumigatus</i> isolates were reviewed, and a complete list of resistant isolates from China, Japan, Taiwan, and Korea is provided. As of this report, the total numbers of tandem-repeat-type azole-resistant isolates are 26, 3, 32, and 1 in China, Japan, Taiwan, and Korea, respectively.

Journal

  • Medical Mycology Journal

    Medical Mycology Journal 59(4), E71-E76, 2018

    The Japanese Society for Medical Mycology

Codes

  • NII Article ID (NAID)
    130007538271
  • NII NACSIS-CAT ID (NCID)
    AA12518136
  • Text Lang
    ENG
  • ISSN
    2185-6486
  • NDL Article ID
    029341581
  • NDL Call No.
    Z19-348
  • Data Source
    NDL  J-STAGE 
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