脂質ナノ粒子を基盤としたがん免疫療法のためのナノDDS開発

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  • 中村 孝司
    北海道大学大学院薬学研究院薬剤分子設計学研究室

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タイトル別名
  • Development of a Nano DDS for Cancer Immunotherapy Based on Llipid Nanoparticles
  • Review for award 脂質ナノ粒子を基盤としたがん免疫療法のためのナノDDS開発
  • Review for award シシツ ナノ リュウシ オ キバン ト シタ ガン メンエキ リョウホウ ノ タメ ノ ナノ DDS カイハツ

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<p>The appearance of immune checkpoint inhibitors has been a major turning point in cancer therapy. The success of immune checkpoint therapy has revolutionized the field of cancer therapy, and immunotherapy has joined the cancer treatment ranks as a pillar. To induce effective anti-tumor immune responses, it is necessary both to enhance the activity of immune cells and to block immune suppression by tumor cells. Carrier type drug delivery systems based on nanobiotechnology (nano DDS) represent a potentially useful technology for efficiently achieving both: enhancement of the activity of immune cells and blocking immune suppression. It has become clear that nano DDS can improve the practical utility of a wide variety of immune functional molecules and thus regulate drug kinetics and intracellular dynamics to improve drug efficacy and reduce side effects. We have been in the process of developing a nano DDS for the enhancement of cancer immunotherapy. A nano DDS encapsulating an agonist of a simulated interferon gene pathway greatly enhanced the activity of the agent's antitumor immune response. To block immune suppression, we successfully developed a small interfering RNA loaded into a nano DDS which regulates gene expression in immune cells. In this review, we summarize our recent efforts regarding cancer immunotherapy using nano DDS.</p>

収録刊行物

  • 薬学雑誌

    薬学雑誌 138 (12), 1443-1449, 2018-12-01

    公益社団法人 日本薬学会

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