i-Motif-Binding Ligands and Their Effects on the Structure and Biological Functions of i-Motif

Access this Article

Author(s)

Abstract

<p>The i-motif is a high-order DNA structure formed by hemiprotonated cytosine–cytosine base pairs under acidic conditions. It is less well studied than other high-order DNA structures, such as G-quadruplexes. However, increasing numbers of i-motif-binding ligands are being reported, and they are being used as tools to investigate the i-motif's structure and biological functions. It has become clear that the i-motif has a functional role in the regulation of gene expression. In this review, we provide an overview of i-motif ligands so far reported, and we summarize their effects on the structure and their use as tools to investigate its biological functions.</p>

Journal

  • Chemical and Pharmaceutical Bulletin

    Chemical and Pharmaceutical Bulletin 66(12), 1091-1103, 2018

    The Pharmaceutical Society of Japan

Codes

  • NII Article ID (NAID)
    130007539147
  • NII NACSIS-CAT ID (NCID)
    AA00602100
  • Text Lang
    ENG
  • ISSN
    0009-2363
  • NDL Article ID
    029360812
  • NDL Call No.
    Z53-D167
  • Data Source
    NDL  J-STAGE 
Page Top