Gamma-Aminobutyric Acid (GABA) Attenuates Ischemia Reperfusion-Induced Alterations in Intestinal Immunity

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著者

    • Kubota Atsuhito Kubota Atsuhito
    • Laboratory of Clinical Pharmaceutics & Therapeutics, Division of Pharmasciences, Faculty of Pharmaceutical Sciences, Hokkaido University
    • Sarashina Sota Sarashina Sota
    • Laboratory of Clinical Pharmaceutics & Therapeutics, Division of Pharmasciences, Faculty of Pharmaceutical Sciences, Hokkaido University
    • Takeno Reiko Takeno Reiko
    • Laboratory of Clinical Pharmaceutics & Therapeutics, Division of Pharmasciences, Faculty of Pharmaceutical Sciences, Hokkaido University
    • Yasuda Genki Yasuda Genki
    • Laboratory of Clinical Pharmaceutics & Therapeutics, Division of Pharmasciences, Faculty of Pharmaceutical Sciences, Hokkaido University
    • Narumi Katsuya Narumi Katsuya
    • Laboratory of Clinical Pharmaceutics & Therapeutics, Division of Pharmasciences, Faculty of Pharmaceutical Sciences, Hokkaido University
    • Furugen Ayako Furugen Ayako
    • Laboratory of Clinical Pharmaceutics & Therapeutics, Division of Pharmasciences, Faculty of Pharmaceutical Sciences, Hokkaido University
    • Iseki Ken Iseki Ken
    • Laboratory of Clinical Pharmaceutics & Therapeutics, Division of Pharmasciences, Faculty of Pharmaceutical Sciences, Hokkaido University|Department of Pharmacy, Hokkaido University Hospital

抄録

<p>The aims of this study were to determine the effects of gamma-aminobutyric acid (GABA) on immunoglobulin A (IgA) secretion from Peyer's patch (PP) cells; to assess rat alpha-defensin-5 (RD-5) expression in the rat small intestine; and to determine the effect of GABA on intestinal ischemia reperfusion (I/R) injury-induced intestinal innate immunity. We found that GABA caused an increase in IgA secretion in the presence and absence of lipopolysaccharide (LPS). Moreover, GABA also significantly increased the mRNA levels of RD-5 and superoxide dismutase (Sod) 1, 3. Intestinal I/R was induced by a 30-min occlusion of the superior mesenteric artery followed by a reperfusion for 60-min. This led to a significant decrease in IgA secretion, and mRNA levels of RD-5 and Sod 1-3 in the ileum. On the other hand, administration of GABA before I/R induction had a significant protective effect against oxidative injury and attenuated the effects on intestinal immunity.</p>

収録刊行物

  • Biological & Pharmaceutical Bulletin

    Biological & Pharmaceutical Bulletin 41(12), 1874-1878, 2018

    公益社団法人 日本薬学会

各種コード

  • NII論文ID(NAID)
    130007539553
  • NII書誌ID(NCID)
    AA10885497
  • 本文言語コード
    ENG
  • ISSN
    0918-6158
  • NDL 記事登録ID
    029361066
  • NDL 請求記号
    Z53-V41
  • データ提供元
    NDL  J-STAGE 
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