Mammalian O-mannosyl glycans : Biochemistry and glycopathology

• ENDO Tamao

  Tokyo Metropolitan Institute of Gerontology

書誌事項

タイトル別名

• Mammalian <i>O</i>-mannosyl glycans: Biochemistry and glycopathology

抄録

Glycosylation is an important posttranslational modification in mammals. The glycans of glycoproteins are classified into two groups, namely, N-glycans and O-glycans, according to their glycan-peptide linkage regions. Recently, O-mannosyl glycan, an O-glycan, has been shown to be important in muscle and brain development. A clear relationship between O-mannosyl glycans and the pathomechanisms of some congenital muscular dystrophies has been established in humans. Ribitol-5-phosphate is a newly identified glycan component in mammals, and its biosynthetic pathway has been elucidated. The discovery of new glycan structures and the identification of highly regulated mechanisms of glycan processing will help researchers to understand glycan functions and develop therapeutic strategies.

収録刊行物

• Ｐｒｏｃｅｅｄｉｎｇｓ　ｏｆ　ｔｈｅ　Ｊａｐａｎ　Ａｃａｄｅｍｙ．　Ｓｅｒ．　Ｂ：　Ｐｈｙｓｉｃａｌ　ａｎｄ　Ｂｉｏｌｏｇｉｃａｌ　Ｓｃｉｅｎｃｅｓ

  Ｐｒｏｃｅｅｄｉｎｇｓ　ｏｆ　ｔｈｅ　Ｊａｐａｎ　Ａｃａｄｅｍｙ．　Ｓｅｒ．　Ｂ：　Ｐｈｙｓｉｃａｌ　ａｎｄ　Ｂｉｏｌｏｇｉｃａｌ　Ｓｃｉｅｎｃｅｓ 95 (1), 39-51, 2019-01-11

  日本学士院

キーワード

• <i>O</i>-mannosylation
• congenital muscular dystrophy
• dystroglycan
• ribitol-5-phosphate

詳細情報

• CRID: 1390845713038475136
• NII論文ID: 130007555822
• NII書誌ID: AA00785485
• DOI: 10.2183/pjab.95.004
• ISSN: 13492896
• ISSN: 03862208
• NDL書誌ID: 029545786
• PubMed: 30643095
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I029545786
• Web Site: https://www.jstage.jst.go.jp/article/pjab/95/1/95_PJA9501B-04/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2020156061
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可