Different daily glycemic profiles after switching from once-daily alogliptin plus twice-daily metformin to their once-daily fixed-dose combination in Japanese type 2 diabetic patients
-
- Takahara Mitsuyoshi
- Department of Diabetes Care Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan
-
- Shiraiwa Toshihiko
- Shiraiwa Medical Clinic, Kashiwara, Osaka 582-0005, Japan
-
- Katakami Naoto
- Department of Metabolism and Atherosclerosis, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan
-
- Maeno Yoshifumi
- Shiraiwa Medical Clinic, Kashiwara, Osaka 582-0005, Japan
-
- Yamamoto Kaoru
- Shiraiwa Medical Clinic, Kashiwara, Osaka 582-0005, Japan
-
- Shiraiwa Yuka
- Shiraiwa Medical Clinic, Kashiwara, Osaka 582-0005, Japan
-
- Yoshida Yoko
- Shiraiwa Medical Clinic, Kashiwara, Osaka 582-0005, Japan
-
- Matsuoka Taka-aki
- Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan
-
- Shimomura Iichiro
- Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan
この論文をさがす
抄録
<p>The aim of this study was to investigate whether daily glycemic profiles and treatment satisfaction would be changed after switching from once-daily 25-mg alogliptin plus twice-daily 250-mg metformin to the fixed-dose combination of 25-mg alogliptin and 500-mg metformin once daily in type 2 diabetic patients. Twenty adult Japanese type 2 diabetic patients in whom once-daily 25-mg alogliptin plus twice-daily 250-mg metformin were switched to the fixed-dose combination of 25-mg alogliptin and 500-mg metformin once daily participated. Before and one month after the switch, participants were asked to perform one day of seven-point self-monitoring of blood glucose (SMBG), to wear a sensor of flash glucose monitoring for up to 14 days, and to respond to a questionnaire for treatment satisfaction. As a result, the SMBG profiles were significantly changed after the switch (p = 0.021); blood glucose levels 2 hours after breakfast were significantly elevated (p = 0.022), whereas those 2 hours after lunch were significantly reduced (p = 0.036). The flash glucose monitoring also demonstrated a significant change of daily glucose profiles (p < 0.001). The risk of glucose levels <80 mg/dL were decreased from evening to morning, while the risk of glucose levels ≥140 mg/dL were increased. Mean 24-hour glucose values were increased by 5 mg/dL on average (p < 0.001). Treatment satisfaction was significantly improved after the switch (p < 0.001). In conclusion, daily glycemic profiles were significantly changed after switching from once-daily 25-mg alogliptin plus twice-daily 250-mg metformin to the once-daily fixed-dose combination in Japanese type 2 diabetic patients. Treatment satisfaction was significantly improved after the switch.</p>
収録刊行物
-
- Endocrine Journal
-
Endocrine Journal 66 (1), 11-17, 2019
一般社団法人 日本内分泌学会