In Vivo Tissue Response of Endodontic Bio-ceramic Materials

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  • Romano Teresita
    Experimental Pathology and Tissue Engineering Laboratory, Oral Pathology Department, Dental School, Tucumán University
  • Jammal María Victoria
    Experimental Pathology and Tissue Engineering Laboratory, Oral Pathology Department, Dental School, Tucumán University
  • Nakano Keisuke
    Department of Oral Pathology and Medicine, Graduate School of Medicine, dentistry and Pharmaceutical Sciences, Okayama University
  • Rusco Ana García
    Postgraduate Department, Dental School, Tucumán University
  • Fassi Jorge Olmos
    Postgraduate Department, Dental School, Tucumán University
  • Kozuszko Silvia
    Experimental Pathology and Tissue Engineering Laboratory, Oral Pathology Department, Dental School, Tucumán University
  • Takabatake Kiyofumi
    Department of Oral Pathology and Medicine, Graduate School of Medicine, dentistry and Pharmaceutical Sciences, Okayama University
  • Nagatsuka Hitoshi
    Department of Oral Pathology and Medicine, Graduate School of Medicine, dentistry and Pharmaceutical Sciences, Okayama University
  • Missana Liliana Raquel
    Experimental Pathology and Tissue Engineering Laboratory, Oral Pathology Department, Dental School, Tucumán University PROIMI-Biotechnology, CONICET, Pilot Plant for Microbial Industrial Processes and Biotechnology

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Abstract

<p>In order to evaluate the biocompatibility and mineral repair capacity, mineral trioxide aggregate (MTA), portland cement normal setting (PCn) and fast setting (PCf) and calcium hydroxide-based paste (Calen) filled silicone tube were implanted into the dorsal subcutaneous connective tissues of 25 Wistar rats. Animals were euthanized at 24, 72 hours, 7, 15 and 30 days. Implants with surrounding tissues were fixed with 10% buffer formaldehyde and processed for histological routine techniques. Slides (5 µm serial cuts) were stained with H&E and Von Kossa stains for morphological, qualitative and quantitative analysis by light microscopy. Calen showed severe and moderate inflammatory response and granulomatous reaction with psammoma body-like formation. PCn and MTA have similar behavior, with mild inflammatory reaction from 8% and 4%, respectively. Even though, PCn and MTA demonstrated analogous biological reaction, MTA developing thick artificial mineral precipitation (p = 0,007). All sealers demonstrated a similar inflammatory response at all time periods studied (p = 0.678).</p>

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