Calcium, Phosphorus and Oxygen Around Implant at Early Osseointegration in Hyperlipidemic Rats

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Author(s)

    • Liu Qibo Liu Qibo
    • Shandong Provincial Key Laboratory of Oral Tissue Regeneration, School of Stomatology, Shandong University|Department of Prosthodontics, School of Stomotology, Shandong University
    • Wang Zhifeng Wang Zhifeng
    • Shandong Provincial Key Laboratory of Oral Tissue Regeneration, School of Stomatology, Shandong University|Department of Pediatric Dentistry, School of Stomotology, Shandong University
    • Dong Xiaofei Dong Xiaofei
    • The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei- MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University
    • Wang Hui Wang Hui
    • Department of Dental Implantology, Affiliated Stomological Hospital of Suzhou University
    • Lan Jing Lan Jing
    • Shandong Provincial Key Laboratory of Oral Tissue Regeneration, School of Stomatology, Shandong University|Department of Prosthodontics, School of Stomotology, Shandong University

Abstract

<p>The study was to observe dental implant osseointegration at early stage and analysis the influencement of the ratio of calcium and phosphorus variation on osseointegration in hyperlipidemic rats. Wistar rats were randomly divided into control group with normal diet and experimental group with high fat diet. 8 weeks later, serum lipid levels was detected and titanium implants were placed into bilateral femurs. At day1, 3, 5 after implant, rats were sacrificed and 5 mm bone with implants was obtained. hard tissue slices and methylene blue-acid fuchsin staining were performed to observe the interface of bone-implant. And energy disperse X-ray spectrometer (EDS) was used to measure the percentage of oxygen and the ratio of calcium and phosphorus. All rats in experimental group were successfully induced into hyperlipidemic status. Histological results revealed less osteoblasts and trabecular bone, but more osteoclasts and trabecular space in experimental group than those in control group. Higher content of oxygen and lower ration of calcium and phosphorus were also observed in experimental group than those in control group (P<0.05). Hyperlipidemia could hinder implant osseointegration at early stage after implantation. This inhibition might be closely related to higher content of oxygen and lower ratio of calcium and phosphorus.</p>

Journal

  • Journal of Hard Tissue Biology

    Journal of Hard Tissue Biology 28(1), 57-62, 2019

    THE SOCIETY FOR HARD TISSUE REGENERATIVE BIOLOGY

Codes

  • NII Article ID (NAID)
    130007585246
  • NII NACSIS-CAT ID (NCID)
    AA11074332
  • Text Lang
    ENG
  • ISSN
    1341-7649
  • NDL Article ID
    029493823
  • NDL Call No.
    Z19-B312
  • Data Source
    NDL  J-STAGE 
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