Association between aldehyde dehydrogenase-2 polymorphisms, alcohol consumption, and prognosis in Japanese patients with hypopharyngeal cancer

• Omura Go

  Department of Head and Neck Surgery, National Cancer Center Hospital Department of Otolaryngology-Head and Neck Surgery, Faculty of Medicine, the University of Tokyo

• Ando Mizuo

  Department of Otolaryngology-Head and Neck Surgery, Faculty of Medicine, the University of Tokyo

• Kobayashi Kenya

  Department of Head and Neck Surgery, National Cancer Center Hospital Department of Otolaryngology-Head and Neck Surgery, Faculty of Medicine, the University of Tokyo

• Fukuoka Osamu

  Department of Otolaryngology-Head and Neck Surgery, Faculty of Medicine, the University of Tokyo

• Akashi Ken

  Department of Otolaryngology-Head and Neck Surgery, Faculty of Medicine, the University of Tokyo

• Saito Yuki

  Department of Otolaryngology-Head and Neck Surgery, Faculty of Medicine, the University of Tokyo

• Yoshida Masafumi

  Department of Otolaryngology-Head and Neck Surgery, Faculty of Medicine, the University of Tokyo

• Yamasoba Tatsuya

  Department of Otolaryngology-Head and Neck Surgery, Faculty of Medicine, the University of Tokyo

Bibliographic Information

Other Title

• 下咽頭癌症例における<i>ALDH2</i>多型と飲酒量および予後についての検討

Abstract

The aim of this study was to evaluate the association between ALDH2 polymorphisms and clinicopathological characteristics of Japanese hypopharyngeal cancer （HPC） patients. <br>We retrospectively reviewed the clinical charts of 63 HPC patients who initially underwent curative intent surgery from 2008 to 2015. ALDH2 polymorphism status was determined using Sanger sequencing. Amount of alcohol consumption was converted using the Sake index. <br>ALDH2*1/*1, ALDH2*1/*2, and ALDH2*2/*2 were found in 27 （43％）, 36 （57％）, and 0 patients, respectively. The Sake index in ALDH2*1/*2 patients was significantly lower than that in ALDH2*1/*1 patients （75.6±9.2 and 114.0±14.5, respectively; P＝0.03）. In contrast, ALDH2 polymorphism status did not correlate with the prognoses of HPC patients.

Journal

• Toukeibu Gan

  Toukeibu Gan 44 (4), 365-369, 2018

  Japan Society for Head and Neck Cancer

Keywords

• Hypopharyngeal cancer
• Alcohol consumption
• <i>ALDH2</i> polymorphisms
• <i>TP53</i> mutations
• Prognosis

Details

• CRID: 1390564238072046464
• NII Article ID: 130007585329
• DOI: 10.5981/jjhnc.44.365
• ISSN: 18818382
• ISSN: 13495747
• Web Site: https://www.jstage.jst.go.jp/article/jjhnc/44/4/44_365/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2019140488
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed